Estimating microRNA levels in periodontal disease and their response to non-surgical therapy.
Not Applicable
- Conditions
- Health Condition 1: K053- Chronic periodontitis
- Registration Number
- CTRI/2021/09/036784
- Lead Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Stage II and Stage III periodontitis patients (4-6mm pocket depth or 3-5 mm loss of attachment) according to the AAP Classification 2018.
2.Patients who have not received periodontal therapy, within preceding six months.
Exclusion Criteria
1.Patients who received treatment with antibiotics/anti-inflammatory drugs in last 3 months.
2.Pregnant and lactating females.
3.Medically compromised patients.
4.Smokers, tobacco chewers and alcoholics.
5.Patients taking high-dose steroid therapy, radiation or immunosuppressive therapy.
6.Mentally retarded and un-cooperative patients.
7.Known history of genetic disorders.
8.Patients not compliant to oral hygiene instructions and recall maintenance.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evels of salivary and serum microRNA 146a, 200c and PTEN gene.Timepoint: Baseline and 8 weeks
- Secondary Outcome Measures
Name Time Method 1.Sulcus bleeding index ( Muhlemann and Son, 1971) <br/ ><br>2.Plaque Index ( Turesky, Gilmore, Glickman modification of Quigley-Hein Plaque Index, 1970) <br/ ><br>3.Probing Pocket Depth(PPD) <br/ ><br>4.Clinical Attachment Loss(CAL)Timepoint: Baseline and 8 weeks