Effects of L-carnitine on genetic, inflammation and antioxidant factors in Nonalcoholic Steatohepatitis patients.

Not Applicable

• Conditions: onalcoholic steatohepatitis.; Nonalcoholic steatohepatitis( NASH)

• Registration Number: IRCT201212052602N8
• Lead Sponsor: Vice Chancellor for Research of Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

Inclusion criteria : age between 18-65 years; BMI=25 kg/m2, under weight loss regimen ; ALT=1.5 fold normal; Sonography showing Nonalcoholic Steatohepatitis ;
Exclusion criteria: not willing toCollaborate; viral hepatitis; taking Insulin; blood lipid-lowering agents;Antiinflammatory drugs(stroid and non stroid) and antioxidant supplements; smoking cigarettes.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TNF-a. Timepoint: At first of the study and 12th week. Method of measurement: labratory kit.;TGF-ß. Timepoint: At first of the study and 12th week. Method of measurement: Sandwich Elisa.;Malondialdehide. Timepoint: At first of the study and 12th week. Method of measurement: Sandwich Elisa.;CRP. Timepoint: At first of the study and 12th week. Method of measurement: labratory kit.;MiRNA-16. Timepoint: At first of the study and 12th week. Method of measurement: RT-PCR.;MiRNA-21. Timepoint: At first of the study and 12th week. Method of measurement: RT-PCR.;MiRNA-217. Timepoint: At first of the study and 12th week. Method of measurement: RT-PCR.