Plasma Free Fatty Acids in Risk Assessment of Sepsis in the Emergency Department: A Prospective Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 74
- 试验地点
- 2
- 主要终点
- Disposition: Admission to hospital or discharge home
研究概览
简要总结
Plasma free fatty acids (FFAs) are thought to play a role in the generation of organ dysfunction. The investigators hypothesize that plasma FFA levels are a marker of poor prognosis in patients with sepsis. The present study will examine the relation between plasma FFA levels and severity of illness in patients with sepsis presenting to the Emergency Department. It will also examine the relation between plasma FFA levels and the risk of developing late morbidity, multiple organ dysfunction syndrome (MODS) and/or mortality during initial hospitalization and over a 30-day follow-up period.
详细描述
The long term objective of this study is to investigate the mechanism by which plasma free fatty acids (FFAs) contribute to the progression of sepsis severity in infectious patients presenting to the Emergency Department. In the present study, pilot data will be generated to validate our hypothesis that elevated free fatty acids are related to outcome in sepsis.
We will examine our hypotheses with the following specific aims:
- To determine if plasma FFA levels are related to severity of illness in patients with sepsis presenting to the Emergency Department.
- To study the prognostic value of plasma FFA levels at predicting future morbidity and mortality in patients with sepsis presenting to the Emergency Department.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years of age or older
- •Able to provide informed consent (or has surrogate present that can do so)
- •Presenting to the Emergency Department (ED) for evaluation
- •Clinical suspicion of infection, as indicated by the ED physician's ordering a blood culture or a current temperature of ≥38C.
排除标准
- •Liver disease
- •Hepatitis
- •Alcohol consumption >2 drinks/day for longer than 6 months
- •Pregnant women
- •Prisoners or other institutionalized individuals
- •Unable to speak the English language
- •Unwilling or unlikely to be reachable by telephone for the 30-day follow-up status assessment call
结局指标
主要结局
Disposition: Admission to hospital or discharge home
时间窗: within 48 h
Hospital length-of-stay
时间窗: 30 days
次要结局
- All cause mortality(30 days)
研究者
Rakesh Engineer
Principal Investigator
The Cleveland Clinic