Effect of IVF culture medium on health of IVF childre

Completed

• Conditions: growth and development; metabolic syndrome; 10018424; 10013317; 10057166

• Registration Number: NL-OMON44948
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-11-30
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 136

Inclusion Criteria

IVF group:
•born after an IVF treatment at the MUMC applied in the period July 2003 - December 2006
CONTROL 1 and 2:
•9 years old
•singleton
Control 3:
• 9 years old
• Singleton
• Have a brother or sister that belongs to the IVF group

Exclusion Criteria

All:
• Mentally retarded defined as not able to understand the child information leaflet
IVF group:
• Born after preimplantation genetic diagnosis (PGD)
CONTROL 1 and 2 and 3:
• conceived by any form of assisted reproduction
CONTROL 2:
• having a disorder that affects lipid profile or glucose metabolism

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameters are blood pressure, heart rate, endothelial<br /><br>function (via iontophoresis and glycocalyx), lipid, TSH, HbA1c, insulin and<br /><br>glucose levels in blood, length, weight, waist and hip circumference and skin<br /><br>fold thickness and cortisol levels in hair. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>DNA methylation in saliva.</p><br>