Minimizing nocebo effects by conditioning with verbal suggestio
Not Applicable
Completed
- Conditions
- Experimentally induced itch in healthy subjectsSigns and Symptoms
- Registration Number
- ISRCTN76895197
- Lead Sponsor
- eiden University
- Brief Summary
2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/28910291 (added 29/01/2019) 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29856465 (added 29/01/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 129
Inclusion Criteria
1. Healthy human volunteers
2. 18 - 35 years old
3. Both male and female
4. Fluent in Dutch language
Exclusion Criteria
1. Severe morbidity (e.g., multiple sclerosis, diabetes mellitus, heart or lung diseases)
2. Psychiatric disorders (e.g., depression)
3. Use of pacemaker
4. Color blindness
5. Diagnose of histamine hypersensitivity
6. Chronic itch or pain complaints
7. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evel of itching, measured using an NRS score, induced by each electrical stimulus
- Secondary Outcome Measures
Name Time Method <br> 1. Scratching behavior, induced by each electrical stimulus. Scratching behaviour is assessed by videotaping the participants during the experiment. Frequency, duration and localization of scratching behaviour are scored by an experimenter who is blinded for the randomization of groups and colored cues.<br> 2. Level of itching (NRS rating) and scratching behavior induced by histamine iontophoresis<br>