Association of Cephalosporin Resistance in Intraoperative Biliary Cultures with Surgical Site Infections in Patients Undergoing Pancreaticoduodenectomy - a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 376
- 试验地点
- 1
- 主要终点
- Prevalence of cephalosporin resistance in intraoperative biliary cultures
研究概览
简要总结
Preoperative biliary drainage predisposes the bile to be contaminated with bacteria of the duodenum. These bacteria colonizing the bile are a potential source for surgical site infections after pancreaticoduodenectomy and many international guidelines recommend the use of cephalosporines as microbial prophylaxis before surgery. The aim of this study was to assess the incidence of bacteria in bile, their resistance profiles and association to surgical site infections in relation to timing of surgery after preoperative biliary drainage in order to better guide antibiotic use.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients undergoing pancreaticoduodenectomy between May 23rd 2016 to October 29th 2020
排除标准
- •Patients without intraoperative biliary culture
- •Patients with unknown date of preoperative biliary culture
结局指标
主要结局
Prevalence of cephalosporin resistance in intraoperative biliary cultures
时间窗: At the time of operation
Rate of surgical site infections
时间窗: 30 days post operatively
次要结局
未报告次要终点
研究者
Timo Tarvainen
Principal Investigator
Helsinki University Central Hospital