Antimicrobial Resistance in Cirrhotic Patients

• Conditions: Cirrhosis
• Interventions: Diagnostic Test: Specimen

• Registration Number: NCT04915573
• Lead Sponsor: Mansoura University

Brief Summary

Cirrhotic patients are more vulnerable to bacterial infection, and infection is one of the most common causes of acute liver disease decompensation.

Detailed Description

Cirrhotic patients are more vulnerable to bacterial infection which is a common cause of acute liver disease decompensation. The aim of this study will characterize the antimicrobial resistance and distribution of bacteria isolated from chronic hepatic patients with pulmonary infections, as well as to evaluate the antimicrobial susceptibility of bacteria isolated from sputum.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2021-05-29
• Status Verified: 2021-06
• Study First Submitted QC: 2021-06-04
• Study Start: 2021-06-07
• Study First Posted: 2021-06-07
• Last Update Submitted: 2021-06-09
• Last Update Posted: 2021-06-10
• Primary Completion: 2021-09
• Study Completion: 2021-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Adults' older than 18 years with clinical evidence of liver disease

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Exclusion Criteria

1. Pregnancy
2. Intensive care unite stay of more than 24 hours
3. Malignancy
4. Organ transplantation
5. Acquired immune deficiency syndrome

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients with Cirrhosis	Specimen	Patient with clinical evidence of liver disease, portal hypertension, ultrasound or computed tomography results, laboratory data will be used to confirm liver disease

Primary Outcome Measures

Name	Time	Method
Isolate Identification	One day	Distribution of bacterial isolates from sputum of cirrhotic patients expressed by frequency of each isolate
Antimicrobial resistance	One day	Antimicrobial susceptibility testing to antibiotics determined by kirby-bauer disk diffusion

Trial Locations

Locations (1)

Tanta University Hospitals; 🇪🇬 Tanta, Egypt