NCT00536718Unknown不适用
GLACIER: A Study to Investigate the Genetics of LobulAr Carcinoma In Situ in EuRope
National Cancer Research Network9 个研究点 分布在 1 个国家目标入组 3,000 人开始时间: 2007年6月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 3,000
- 试验地点
- 9
- 主要终点
- Inherited variation predisposing development of lobular carcinoma in situ (LCIS) of the breast in women
研究概览
简要总结
RATIONALE: Gathering information about genetic changes in patients with lobular carcinoma in situ of the breast may help doctors learn more about the disease and find better methods of treatment.
PURPOSE: This clinical trial is studying the genetics of women with lobular carcinoma in situ of the breast.
详细描述
OBJECTIVES:
Primary
- Identify inherited variation that predisposes women to develop lobular carcinoma in situ (LCIS) of the breast.
- Identify the frequency of these variants and determine the effect they have on tumor risk.
- Determine how worthwhile it would be to test for these variants in the clinical setting so that those at higher risk could be identified, counseled, and screened.
Secondary
- Analysis of genetic changes within LCIS with the aim of identifying cases of LCIS which may progress to invasive cancer.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- — 至 60 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Inherited variation predisposing development of lobular carcinoma in situ (LCIS) of the breast in women
Clinical setting variant test value in identifying, counseling and screening those women at higher risk
Frequency and effect of variants on tumor risk
次要结局
- LCIS genetic changes which may progress to invasive cancer
研究者
研究点 (9)
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