The intervention of acupuncture and traditional Chinese medicine 'pre cultivate its damage' on IVF / ICSI-ET outcome of elderly dor women with kidney deficiency and the regulation of microbiome and local immune response of cervicovaginal: a prospective cohort study

Phase 1

• Conditions: Infertility

• Registration Number: ITMCTR2000003102
• Lead Sponsor: Tongji Hospital Affiliated to Tongji University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

1. Aged between 35 and 42 years old;
2. Patients with indications for IVF / ICSI-ET;
3. Patients meeting the diagnostic criteria of Dor;
4. Patients in accordance with the diagnosis of kidney deficiency syndrome in traditional Chinese medicine;
5. The main causes of infertility are fallopian tube factors rather than hypothalamus and other endocrine diseases(hypothyroidism or hyperthyroidism, diabetes, etc.), polycystic ovary syndrome (PCOS), severe pelvic endometriosis, adenomyosis, etc.;
6. Patients agree to participate in this clinical study and sign an informed consent form.

Exclusion Criteria

1. Patients with a history of steroid therapy and uterine cavity operation within 3 months;
2. Patients with clear and serious other organic diseases of reproductive organs;
3. With ovarian premature failure, previous ovarian surgery history and only single ovarian;
4. With PCOS, adenomyosis, uterine malformations, chromosomal abnormalities, ovarian tumors, and other endocrine diseases(diabetes, thyroid dysfunction, etc.);
5. With hereditary diseases that are not suitable for production, and are currently not capable of being diagnosed by preimplantation genetics under the Maternal and Child Health Act;
6. The couple merged with Severe primary diseases of the cardiovascular, hepatic, renal or hematopoietic systems , or with mental illness;
7. Either of the couple has serious addictions such as drug use and exposure to teratogenic rays, poisons, and drugs and is in the action period;
8. With allergic constitution and allergy to many drugs;
9. Can not insist on treatment.

Study & Design

• Study Type: Observational study
• Study Design: Not specified