Acupuncture and Chinese Herbal Medicine to improve live birth rate of in vitro fertilization: a randomized controlled trial
Not Applicable
- Conditions
- in vitro fertilization - embryo transfer
- Registration Number
- ITMCTR2000003267
- Lead Sponsor
- The First Affiliated Hospital, Heilongjiang University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
1. Women >= 20 to <=40 years of age;
2. Indications for IVF;
3. Duration of infertility >1 year;
4. Undergoing IVF with an intention of fresh ET on day 3 or 5.
Exclusion Criteria
1. Women with an intention to replace frozen embryos only.
2. Preimplantation genetic testing.
3. History of recurrent miscarriages defined as having three consecutive miscarriages.
4. Having acupuncture or CHM for infertility within 3 months prior the IVF.
5. Women with abnormal liver or renal function tests.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ive birth;
- Secondary Outcome Measures
Name Time Method Cumulative live birth rate within 6 months after randomization;Patient acceptability of acupuncture to be measured at the end of the intervention.;Miscarriage rate;Side effects;Congenital abnormalities;Physical growth parameters and neurological development of children up to 3 years of age;Changes in markers of stress, anxiety and HRQoL;Implantation rate;Ongoing pregnancy rate (=8 weeks);Ectopic pregnancy rate;Embryo quality;Positive serum hCG level (2 weeks after ET);Multiple pregnancy rate;Cost effectiveness analyses (after the interim analysis);Pregnancy complications;