FINDING OF HEART PROBLEMS IN DIABETIC PATIENTS

Not yet recruiting

• Conditions: Type 2 diabetes mellitus with circulatory complications,

• Registration Number: CTRI/2023/07/055615
• Lead Sponsor: DrGAURAV SINGH

Brief Summary

Left ventricular diastolic function (LVDF) isaffected earlier than systolic function in the development of congestivecardiac failure. Therefore, left ventricular diastolic dysfunction mayrepresent the first stage of diabetic cardiomyopathy

Echocardiography is the best noninvasive way to evaluate diastolic function andto estimate filling pressures. M-Mode, two-dimensional, and Doppler echocardiography are all helpful in evaluatingdiastolic function. So the present study will be undertaken to evaluate leftventricular dysfunction in type 2 Diabetes mellitus patients using echocardiographicevaluation

Transthoracic echocardiography will be performed bytrained operator, using a GE VERSANA BALANCE Ultrasound System. Echocardiographerwill not be aware of this study to avoid bias in the interpretation. The leftventricular systolic func­tion measurement will be based on the Teichoiz methodwhile diastolic function will be based on the Doppler recording of leftventricular filling dynamics. The peak velocities of left ventricle fillingduring the early rapid (E wave m/seconds) and atrial contraction (A wave,m/second) phases, the ratio of the two filling velocities (E/A ratio), E wavedeceleration time (DT in milliseconds) from the peak of the E wave to theportion at which the deceleration velocity reaches the base­line and theisovolumic relaxation time (IVRT milliseconds), the time from aortic valveclosure to the beginning of the E wave will be recorded at the end of expirationfor five con­secutive beats. Valsalva maneuver will be performed to unmaskpseudo normal filling.

A reduced E/A ratio of<1 and increase in the size of LA will be considered to be evidence of leftventricular diastolic dysfunction.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-07-15
• Study Start: 2023-07-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Cases of type 2 diabetes mellitus, which clinically have no symptoms of cardiovascular disease Age -18-65 years.

Exclusion Criteria

• •Myocardial infarction by history and resting Electrocardiogram (ECG) •Patients with angina pectoris • Patients with hypertension •Type 1 DM patients •Significant alcoholic patients •Patients with thyroid diseases •Patients with renal failure •Patients with other underlying heart diseases such as: I.
• Congenital heart disease II.
• Valvular heart disease III.
• Pericardial disease – by history, chest X-ray (CXR) posteroanterior (PA) view, and echocardiography (Echo) •Patients with regional wall motion abnormalities are excluded by Echo •Patients not giving consent to participate.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the clinical and an echocardiographic evaluation of left ventricular diastolic dysfunction in type 2 diabetes mellitus patients	2 WEEKS 4 WEEKS 6 WEEKS

Secondary Outcome Measures

Name	Time	Method
To assess the clinical Profile of left ventricular dysfunction in type 2 diabetic patients using Echocardiogram.	2. To correlate left ventricular dysfunction with duration of diabetes

Trial Locations

Locations (1)

VARUN ARJUN MEDICAL COLLEGE AND ROHILKHAND HOSPITAL; 🇮🇳 Shahjahanpur, UTTAR PRADESH, India

VARUN ARJUN MEDICAL COLLEGE AND ROHILKHAND HOSPITAL

🇮🇳Shahjahanpur, UTTAR PRADESH, India

GAURAV SINGH

Principal investigator

9557121007

dr.gaurav.md007@gmail.com