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Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage

Conditions
Left Ventricular Diastolic Dysfunction
Registration Number
NCT04549298
Lead Sponsor
Neuromed IRCCS
Brief Summary

Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures. Currently, it is possible to classify it in 3 grades: grade 1 with normal filling pressures, grade 2 and grade 3 with high pressures. Diastolic dysfunction is closely associated with several risk factors such as hypertension, diabetes, and obesity, as well as the risk of heart failure, cardiovascular events, and death. In the field of cerebrovascular diseases, however, diastolic dysfunction is still being researched. Thus, this study aims to: 1) evaluate the white matter hyperintensities volume in association with the increase of diastolic dysfunction and filling pressures 2) evaluate the possible association with carotid atherosclerosis in case of brain damage caused by dysfunction diastolic 3) understand the mechanism of damage caused by left ventricular diastolic dysfunction on the cerebrovascular system. In order to do this, this study proposes to evaluate in a cohort of patients, between 35 and 65 years, the possible association of diastolic dysfunction with lesions on the cerebrovascular system in a future view of new marker of brain damage and new modifiable risk factor.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
88
Inclusion Criteria
  • age ≥ 35 and ≤ 65 years
  • written informed consent
Exclusion Criteria
  • previous stroke or TIA
  • arrhythmia or severe cardiac disease
  • renal disease
  • psychiatric disease
  • neurological or neurodegenerative disease
  • dementia
  • previous carotid artery stenting or carotid surgery
  • inability to be subjected MRI analysis

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Measurement of white matter hyperintensities volumeAt Enrollment

Brain MRI

Secondary Outcome Measures
NameTimeMethod
Characterization of cardiac overload with blood markersAt Enrollment

NT-proBNP

Detection of plaques and carotid atherosclerosisAt Enrollment

Ultrasound of the supraortic trunks

Detection of cognitive decline by decrease of MoCA scoreAt Enrollment

Cognitive tests

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