Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage
- Conditions
- Left Ventricular Diastolic Dysfunction
- Registration Number
- NCT04549298
- Lead Sponsor
- Neuromed IRCCS
- Brief Summary
Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures. Currently, it is possible to classify it in 3 grades: grade 1 with normal filling pressures, grade 2 and grade 3 with high pressures. Diastolic dysfunction is closely associated with several risk factors such as hypertension, diabetes, and obesity, as well as the risk of heart failure, cardiovascular events, and death. In the field of cerebrovascular diseases, however, diastolic dysfunction is still being researched. Thus, this study aims to: 1) evaluate the white matter hyperintensities volume in association with the increase of diastolic dysfunction and filling pressures 2) evaluate the possible association with carotid atherosclerosis in case of brain damage caused by dysfunction diastolic 3) understand the mechanism of damage caused by left ventricular diastolic dysfunction on the cerebrovascular system. In order to do this, this study proposes to evaluate in a cohort of patients, between 35 and 65 years, the possible association of diastolic dysfunction with lesions on the cerebrovascular system in a future view of new marker of brain damage and new modifiable risk factor.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 88
- age ≥ 35 and ≤ 65 years
- written informed consent
- previous stroke or TIA
- arrhythmia or severe cardiac disease
- renal disease
- psychiatric disease
- neurological or neurodegenerative disease
- dementia
- previous carotid artery stenting or carotid surgery
- inability to be subjected MRI analysis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of white matter hyperintensities volume At Enrollment Brain MRI
- Secondary Outcome Measures
Name Time Method Characterization of cardiac overload with blood markers At Enrollment NT-proBNP
Detection of plaques and carotid atherosclerosis At Enrollment Ultrasound of the supraortic trunks
Detection of cognitive decline by decrease of MoCA score At Enrollment Cognitive tests