Pediatric Hypertension Registry (PHREG)

Terminated

• Conditions: Hypertension; Pediatric Disorder

• Registration Number: NCT03305562
• Lead Sponsor: Wake Forest University Health Sciences

Brief Summary

Pediatric hypertension is increasingly common and is a precursor for adult cardiovascular and renal disease. But even during childhood, hypertension is associated with significant morbidity, including cognitive impairment and organ damage. However, the cause of pediatric hypertension, the response to treatment, and the mechanisms behind organ damage are incompletely understood. Due to these limitations, there are no first-line medications, and treatment is often inadequate. An improved comprehension of the course of pediatric hypertension could enhance clinical care. The goal of this proposal is to create a registry of patients with hypertension to better enable research into this important disease. This patient registry will enhance the investigators ability to quickly collect and analyze data for research studies.

Detailed Description

The investigators will include all subjects evaluated at the Brenner Children's Hospital Pediatric Nephrology clinic since January 1st, 2013 with a diagnosis of high blood pressure confirmed with three separate blood pressure measurements \>=90th percentile for age, sex, and height, or \>120/80 mmHg. The investigators will exclude patients whose initial evaluation occurred on or after their 18th birthday.

Study Timeline

• Study Start: 2017-09-20
• Study First Submitted: 2017-09-27
• Study First Submitted QC: 2017-10-03
• Study First Posted: 2017-10-10
• Primary Completion: 2021-06-22
• Study Completion: 2021-06-22
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-08
• Last Update Posted: 2023-06-12

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 179

Inclusion Criteria

• Patients at one of the following : Wake Forest Baptist Health Brenner Children's Hospital Pediatric Nephrology clinic Emory University Pediatric Nephrology

• Diagnosis of hypertension confirmed with three separate blood pressure measurements
• Diagnosis after January 2013
• >90th percentile for age, sex, height, or >120/80.

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Exclusion Criteria

• Patients whose initial evaluation occurred on or after their 18th birthday.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure	10 years	Auscultated blood pressure measurements in clinic
Left ventricular hypertrophy	10 years	Left ventricular hypertrophy and other cardiac structural/function changes on echocardiograms
Albuminuria	10 years	Urinary albumin-to-creatinine (\>30 mg/g)

Secondary Outcome Measures

Name	Time	Method
Renal function	10 years	Glomerular filtration rate
Uric acid	10 years	Serum uric acid
Ambulatory blood pressure	10 years	Ambulatory blood pressure monitoring data

Trial Locations

Locations (2)

Emory University Pediatric Nephrology; 🇺🇸 Atlanta, Georgia, United States

Wake Forest University Baptist Medical Center; 🇺🇸 Winston-Salem, North Carolina, United States