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临床试验/NCT03305562
NCT03305562
终止
不适用

Pediatric Hypertension Registry (PHREG)

Wake Forest University Health Sciences2 个研究点 分布在 1 个国家目标入组 179 人2017年9月20日

概览

阶段
不适用
干预措施
未指定
疾病 / 适应症
Hypertension
发起方
Wake Forest University Health Sciences
入组人数
179
试验地点
2
主要终点
Blood pressure
状态
终止
最后更新
2年前

概览

简要总结

Pediatric hypertension is increasingly common and is a precursor for adult cardiovascular and renal disease. But even during childhood, hypertension is associated with significant morbidity, including cognitive impairment and organ damage. However, the cause of pediatric hypertension, the response to treatment, and the mechanisms behind organ damage are incompletely understood. Due to these limitations, there are no first-line medications, and treatment is often inadequate. An improved comprehension of the course of pediatric hypertension could enhance clinical care. The goal of this proposal is to create a registry of patients with hypertension to better enable research into this important disease. This patient registry will enhance the investigators ability to quickly collect and analyze data for research studies.

详细描述

The investigators will include all subjects evaluated at the Brenner Children's Hospital Pediatric Nephrology clinic since January 1st, 2013 with a diagnosis of high blood pressure confirmed with three separate blood pressure measurements \>=90th percentile for age, sex, and height, or \>120/80 mmHg. The investigators will exclude patients whose initial evaluation occurred on or after their 18th birthday.

注册库
clinicaltrials.gov
开始日期
2017年9月20日
结束日期
2021年6月22日
最后更新
2年前
研究类型
Observational
性别
All

研究者

入排标准

入选标准

  • Patients at one of the following : Wake Forest Baptist Health Brenner Children's Hospital Pediatric Nephrology clinic Emory University Pediatric Nephrology
  • Diagnosis of hypertension confirmed with three separate blood pressure measurements
  • Diagnosis after January 2013
  • \>90th percentile for age, sex, height, or \>120/80.

排除标准

  • Patients whose initial evaluation occurred on or after their 18th birthday.

结局指标

主要结局

Blood pressure

时间窗: 10 years

Auscultated blood pressure measurements in clinic

Left ventricular hypertrophy

时间窗: 10 years

Left ventricular hypertrophy and other cardiac structural/function changes on echocardiograms

Albuminuria

时间窗: 10 years

Urinary albumin-to-creatinine (\>30 mg/g)

次要结局

  • Ambulatory blood pressure(10 years)
  • Renal function(10 years)
  • Uric acid(10 years)

研究点 (2)

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