Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- Change in Plasma Angiotensin-(1-7) Level
研究概览
简要总结
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, vasculature, and brain. Recruiting children with a new hypertension diagnosis over a 2-year period from the Hypertension and Pediatric Nephrology Clinics affiliated with Brenner Children's Hospital at Atrium Health Wake Forest Baptist and Atrium Health Levine Children's Hospital. Healthy control participants will be recruited from local general primary care practices. Collecting blood and urine samples to analyze components of the renin-angiotensin-aldosterone system (Ang-(1-7), ACE2, Ang II, ACE), uric acid, and klotho, and measuring blood pressure, heart structure and function, autonomic function, vascular function, and kidney function at baseline, year 1, and year 2. Objectives are to investigate phenotypic and treatment response variability and to causally infer if Ang-(1-7), ACE2, Ang II, ACE, uric acid, and klotho contribute to target organ injury due to hypertension.
详细描述
This longitudinal prospective cohort study is recruiting children and adolescents aged 7-18 years with newly diagnosed primary hypertension over a 2-year period from the Hypertension and Pediatric Nephrology Clinics affiliated with Brenner Children's Hospital at Atrium Health Wake Forest Baptist, which sees over 300 new patients a year, and the Pediatric Nephrology Clinic at Atrium Health Levine Children's Hospital (Hypertension Cohort). Also recruiting healthy control participants aged 7-18 years with normal blood pressure from local primary care practices (Control Cohort). Collecting blood and urine to analyze Ang-(1-7), ACE2, Ang II, ACE, uric acid, and klotho and measuring pediatric-specific outcomes (blood pressure (casual and ambulatory monitoring), indices of heart structure and function on echocardiogram (left ventricular systolic and diastolic function, left ventricular hypertrophy, etc.), kidney function (creatinine, estimated glomerular filtration rate, albuminuria, proteinuria, urine sodium/potassium), autonomic function (heart rate variability, blood pressure variability, baroreflex sensitivity), and vascular function (arterial stiffness, augmentation index)) at baseline and year 1 (Hypertension Cohort and Control Cohort) and year 2 (Hypertension Cohort). The objectives are to investigate if Ang-(1-7), ACE2, Ang II, and ACE identify phenotypic and treatment response variability and to causally infer if Ang-(1-7), ACE2, Ang II, ACE, uric acid, and klotho contribute to target organ injury, with these Specific Aims:
Aim 1:
(1) Determine if plasma Ang-(1-7) or urine Ang-(1-7)/creatinine differ between the Hypertension vs. Control Cohorts and (2) assess if plasma Ang-(1-7) or urine Ang-(1-7)/creatinine mediate the effect of lisinopril-induced blood pressure reduction on the outcomes (change in heart function and structure, autonomic function, vascular function, and kidney function).
Hypothesis 1a: Baseline Ang-(1-7) is lower in the Hypertension vs. Control Cohort.
Hypothesis 1b: Increased Ang-(1-7) levels over time mediate the effect of lisinopril-induced decreased blood pressure on improved outcomes over 2 years in the Hypertension Cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Change in Plasma Angiotensin-(1-7) Level
时间窗: Baseline through 2 years
Plasma angiotensin-(1-7) quantified by a highly developed radioimmunoassay well validated against mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Serum Uric Acid Level
时间窗: Baseline
Serum uric acid quantified by a validated uricase assay. Report as a continuous variable with measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Baseline Plasma Angiotensin II/Angiotensin-(1-7) Ratio
时间窗: Baseline
Plasma angiotensin II and angiotensin-(1-7) quantified by highly developed radioimmunoassays well validated against mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Plasma Angiotensin II/Angiotensin-(1-7) Ratio
时间窗: Baseline through 2 years
Plasma angiotensin II and angiotensin-(1-7) quantified by highly developed radioimmunoassays well validated against mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Plasma Klotho Level
时间窗: Baseline through 2 years
Plasma α-klotho quantified by a well-validated ELISA. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Manual Systolic Blood Pressure
时间窗: Baseline
Average of 3 manual measurements per national guidelines. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Baseline Manual Systolic Blood Pressure Z-score
时间窗: Baseline
Average of 3 manual measurements per national guidelines with calculated z-score referenced to normative values by age, sex, and height. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Change in Serum Uric Acid Level
时间窗: Baseline through 2 years
Serum uric acid quantified by a validated uricase assay. Report as a continuous variable with measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Baseline Manual Diastolic Blood Pressure Z-score
时间窗: Baseline
Average of 3 manual measurements per national guidelines with calculated z-score referenced to normative values by age, sex, and height. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Baseline Left Ventricular Mass Height Index
时间窗: Baseline
Left ventricular mass measured via echocardiogram and indexed to height as g/m\^2.7. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Left Ventricular Mass Height Index
时间窗: Baseline through 2 years
Left ventricular mass measured via echocardiogram and indexed to height as g/m\^2.7. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Left Ventricular Mass Body Surface Area Index
时间窗: Baseline through 2 years
Left ventricular mass measured via echocardiogram and indexed to body surface area (BSA) as g/BSA. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Plasma Renin Activity
时间窗: Baseline through 2 years
Measured in the plasma with a well-validated assay. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Serum Aldosterone Level
时间窗: Baseline
Measured in the serum with a well-validated assay. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Urine Angiotensin-(1-7)/Creatinine Ratio
时间窗: Baseline
Urine angiotensin-(1-7) quantified by a highly developed radioimmunoassay well validated against mass spectrometry and standardized to urine creatinine, quantified by a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Plasma Angiotensin-(1-7) Level
时间窗: Baseline
Plasma angiotensin-(1-7) quantified by a highly developed radioimmunoassay well validated against mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Urine Klotho/Creatinine Ratio
时间窗: Baseline through 2 years
Urine α-klotho quantified by a well-validated ELISA and standardized to urine creatinine, quantified by a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Ambulatory Systolic Blood Pressure 24-Hour Mean
时间窗: Baseline
Measured via ambulatory blood pressure (BP) monitoring. Average systolic BP over a 24-hour period. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Left Ventricular Hypertrophy
时间窗: Baseline through 2 years
Measured via echocardiogram. Binary variable defined as left ventricular mass index (LVMI) \>51 g/m\^2.7 (all participants), \>115 g/body surface area (BSA) (males), or \>95 g/BSA (females), per national guidelines. Report relative measures (e.g., risk ratio) and measures of dispersion (e.g., 95 percent confidence interval).
Baseline Estimated Glomerular Filtration Rate
时间窗: Baseline
Estimated using validated, non-race-based, age-appropriate equations (modified Schwartz equation and height- and age-based full-age-spectrum equations with serum creatinine (analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry) and serum cystatin C (analyzed via the Clinical Laboratory). Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Urine Angiotensin-(1-7)/Creatinine Ratio
时间窗: Baseline through 2 years
Urine angiotensin-(1-7) quantified by a highly developed radioimmunoassay well validated against mass spectrometry and standardized to urine creatinine, quantified by a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Urine Angiotensin II/Angiotensin-(1-7) Ratio
时间窗: Baseline
Urine angiotensin II and angiotensin-(1-7) quantified by highly developed radioimmunoassays well validated against mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Urine Angiotensin II/Angiotensin-(1-7) Ratio
时间窗: Baseline through 2 years
Urine angiotensin II and angiotensin-(1-7) quantified by highly developed radioimmunoassays well validated against mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Ambulatory Diastolic Blood Pressure 24-Hour Mean
时间窗: Baseline
Measured via ambulatory blood pressure (BP) monitoring. Average diastolic BP over a 24-hour period. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Albuminuria
时间窗: Baseline through 2 years
Measured in fasting first-morning urine samples. Albumin analyzed in the Clinical Laboratory and creatinine analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Binary variable defined as an albumin/creatinine ratio \>30 mg/g. Report relative measures (e.g., risk ratio) and measures of dispersion (e.g., 95 percent confidence interval).
Baseline Plasma Klotho Level
时间窗: Baseline
Plasma α-klotho quantified by a well-validated ELISA. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Urine Klotho/Creatinine Ratio
时间窗: Baseline
Urine α-klotho quantified by a well-validated ELISA and standardized to urine creatinine, quantified by a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Manual Systolic Blood Pressure
时间窗: Baseline through 2 years
Average of 3 manual measurements per national guidelines. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Baseline Manual Diastolic Blood Pressure
时间窗: Baseline
Average of 3 manual measurements per national guidelines. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Change in Manual Diastolic Blood Pressure
时间窗: Baseline through 2 years
Average of 3 manual measurements per national guidelines. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Change in Manual Systolic Blood Pressure Z-score
时间窗: Baseline through 2 years
Average of 3 manual measurements per national guidelines with calculated z-score referenced to normative values by age, sex, and height. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Change in Manual Diastolic Blood Pressure Z-score
时间窗: Baseline through 2 years
Average of 3 manual measurements per national guidelines with calculated z-score referenced to normative values by age, sex, and height. Report measures of central tendency (e.g., mean) and dispersion (e.g., standard deviation, 95 percent confidence interval).
Change in Ambulatory Systolic Blood Pressure 24-Hour Mean
时间窗: Baseline through 2 years
Measured via ambulatory blood pressure (BP) monitoring. Average systolic BP over a 24-hour period. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Ambulatory Diastolic Blood Pressure 24-Hour Mean
时间窗: Baseline through 2 years
Measured via ambulatory blood pressure (BP) monitoring. Average diastolic BP over a 24-hour period. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Left Ventricular Mass Body Surface Area Index
时间窗: Baseline
Left ventricular mass measured via echocardiogram and indexed to body surface area (BSA) as g/BSA. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Left Ventricular Hypertrophy
时间窗: Baseline
Measured via echocardiogram. Binary variable defined as left ventricular mass index (LVMI) \>51 g/m\^2.7 (all participants), \>115 g/body surface area (BSA) (males), or \>95 g/BSA (females), per national guidelines. Report relative measures (e.g., risk ratio) and measures of dispersion (e.g., 95 percent confidence interval).
Baseline Urine Albumin/Creatinine Ratio
时间窗: Baseline
Measured in fasting first-morning urine samples. Albumin analyzed in the Clinical Laboratory and creatinine analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Albuminuria
时间窗: Baseline
Measured in fasting first-morning urine samples. Albumin analyzed in the Clinical Laboratory and creatinine analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Binary variable defined as an albumin/creatinine ratio \>30 mg/g. Report relative measures (e.g., risk ratio) and measures of dispersion (e.g., 95 percent confidence interval).
Baseline Serum Creatinine Level
时间窗: Baseline
Measured in the serum and analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Plasma Renin Activity
时间窗: Baseline
Measured in the plasma with a well-validated assay. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Serum Aldosterone Level
时间窗: Baseline through 2 years
Measured in the serum with a well-validated assay. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Urine Albumin/Creatinine Ratio
时间窗: Baseline through 2 years
Measured in fasting first-morning urine samples. Albumin analyzed in the Clinical Laboratory and creatinine analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Serum Creatinine Level
时间窗: Baseline through 2 years
Measured in the serum and analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Estimated Glomerular Filtration Rate
时间窗: Baseline through 2 years
Estimated using validated, non-race-based, age-appropriate equations (modified Schwartz equation and height- and age-based full-age-spectrum equations with serum creatinine (analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry) and serum cystatin C (analyzed via the Clinical Laboratory). Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Urine Sodium Concentration
时间窗: Baseline through 2 years
Measured sodium and creatinine in fasting, first-morning urine samples. Sodium analyzed in the Clinical Laboratory, and creatinine analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Urine Sodium/Potassium Ratio
时间窗: Baseline
Measured sodium and potassium in fasting, first-morning urine samples and analyzed in the Clinical Laboratory. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Baseline Urine Sodium Concentration
时间窗: Baseline
Measured sodium and creatinine in fasting, first-morning urine samples. Sodium analyzed in the Clinical Laboratory, and creatinine analyzed via a modified Jaffe assay traceable to isotope dilution mass spectrometry. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
Change in Urine Sodium/Potassium Ratio
时间窗: Baseline through 2 years
Measured sodium and potassium in fasting, first-morning urine samples and analyzed in the Clinical Laboratory. Report measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation, interquartile range, 95 percent confidence interval).
次要结局
- Baseline Serum Angiotensin-Converting Enzyme/Angiotensin-Converting Enzyme 2 Ratio(Baseline)
- Baseline Hyperuricemia(Baseline)
- Change in Ambulatory Systolic Blood Pressure 24-Hour Index(Baseline through 2 years)
- Baseline Ambulatory Systolic Blood Pressure Awake Mean(Baseline)
- Baseline Ambulatory Systolic Blood Pressure Awake Load(Baseline)
- Change in Urine Angiotensin-Converting Enzyme 2 Level(Baseline through 2 years)
- Baseline Urine Angiotensin-Converting Enzyme Level(Baseline)
- Change in Urine Angiotensin-Converting Enzyme Level(Baseline through 2 years)
- Change in Urine Angiotensin-Converting Enzyme/Angiotensin-Converting Enzyme 2 Ratio(Baseline through 2 years)
- Baseline Plasma Angiotensin II Level(Baseline)
- Change in Serum Angiotensin-Converting Enzyme Level(Baseline through 2 years)
- Change in Manual Blood Pressure Classification(Baseline through 2 years)
- Baseline Urine Angiotensin II/Creatinine Ratio(Baseline)
- Change in Serum Angiotensin-Converting Enzyme 2 Level(Baseline through 2 years)
- Change in Hyperuricemia(Baseline through 2 years)
- Change in Ambulatory Diastolic Blood Pressure 24-Hour Load(Baseline through 2 years)
- Change in Ambulatory Diastolic Blood Pressure 24-Hour Index(Baseline through 2 years)
- Change in Ambulatory Diastolic Blood Pressure Asleep Mean(Baseline through 2 years)
- Baseline Ambulatory Systolic Blood Pressure Asleep Index(Baseline)
- Change in Ambulatory Systolic Blood Pressure Asleep Index(Baseline through 2 years)
- Baseline Relative Left Ventricular Wall Thickness(Baseline)
- Baseline Left Ventricular Diastolic Function(Baseline)
- Baseline Left Atrial Size(Baseline)
- Change in Urine Angiotensin II/Creatinine Ratio(Baseline through 2 years)
- Change in Plasma Angiotensin II Level(Baseline through 2 years)
- Change in Serum Angiotensin-Converting Enzyme/Angiotensin-Converting Enzyme 2 Ratio(Baseline through 2 years)
- Baseline Ambulatory Systolic Blood Pressure 24-Hour Load(Baseline)
- Baseline Ambulatory Diastolic Blood Pressure 24-Hour Load(Baseline)
- Baseline Ambulatory Diastolic Blood Pressure Awake Mean(Baseline)
- Baseline Ambulatory Diastolic Blood Pressure Awake Load(Baseline)
- Change in Ambulatory Diastolic Blood Pressure Awake Load(Baseline through 2 years)
- Change in Ambulatory Systolic Blood Pressure Asleep Load(Baseline through 2 years)
- Change in Ambulatory Diastolic Blood Pressure Nocturnal Dipping(Baseline through 2 years)
- Baseline Left Atrial Enlargement(Baseline)
- Baseline Serum Cystatin C Level(Baseline)
- Change in Serum Cystatin C Level(Baseline through 2 years)
- Change in Elevated Urine Sodium Concentration(Baseline through 2 years)
- Baseline Urine Angiotensin-Converting Enzyme 2 Level(Baseline)
- Baseline Urine Angiotensin-Converting Enzyme/Angiotensin-Converting Enzyme 2 Ratio(Baseline)
- Baseline Serum Angiotensin-Converting Enzyme 2 Level(Baseline)
- Baseline Serum Angiotensin-Converting Enzyme Level(Baseline)
- Baseline Manual Blood Pressure Classification(Baseline)
- Change in Ambulatory Systolic Blood Pressure 24-Hour Load(Baseline through 2 years)
- Change in Ambulatory Diastolic Blood Pressure Awake Mean(Baseline through 2 years)
- Change in Ambulatory Diastolic Blood Pressure Awake Index(Baseline through 2 years)
- Baseline Ambulatory Systolic Blood Pressure Asleep Mean(Baseline)
- Baseline Ambulatory Systolic Blood Pressure Asleep Load(Baseline)
- Baseline Ambulatory Diastolic Blood Pressure Nocturnal Dipping(Baseline)
- Baseline Ambulatory Inadequate Nocturnal Dipping(Baseline)
- Baseline Elevated Relative Left Ventricular Wall Thickness(Baseline)
- Baseline Left Ventricular Systolic Function(Baseline)
- Change in Left Atrial Size(Baseline through 2 years)
- Change in Left Atrial Enlargement(Baseline through 2 years)
- Baseline Urine Uric Acid/Creatinine Ratio(Baseline)
- Change in Urine Uric Acid Per Glomerular Filtration Rate(Baseline through 2 years)
- Change in Urine Fibroblast Growth Factor 23 Level(Baseline through 2 years)
- Baseline Ambulatory Systolic Blood Pressure 24-Hour Index(Baseline)
- Baseline Ambulatory Diastolic Blood Pressure 24-Hour Index(Baseline)
- Change in Ambulatory Systolic Blood Pressure Awake Mean(Baseline through 2 years)
- Baseline Ambulatory Diastolic Blood Pressure Awake Index(Baseline)
- Change in Ambulatory Systolic Blood Pressure Asleep Mean(Baseline through 2 years)
- Baseline Ambulatory Diastolic Blood Pressure Asleep Load(Baseline)
- Change in Ambulatory Diastolic Blood Pressure Asleep Load(Baseline through 2 years)
- Change in Ambulatory Diastolic Blood Pressure Asleep Index(Baseline through 2 years)
- Baseline Ambulatory Systolic Blood Pressure Nocturnal Dipping(Baseline)
- Baseline Ambulatory Hypertension(Baseline)
- Change in Ambulatory Systolic Blood Pressure Awake Load(Baseline through 2 years)
- Baseline Ambulatory Systolic Blood Pressure Awake Index(Baseline)
- Change in Ambulatory Systolic Blood Pressure Awake Index(Baseline through 2 years)
- Baseline Ambulatory Diastolic Blood Pressure Asleep Mean(Baseline)
- Baseline Ambulatory Diastolic Blood Pressure Asleep Index(Baseline)
- Change in Ambulatory Systolic Blood Pressure Nocturnal Dipping(Baseline through 2 years)
- Change in Ambulatory Inadequate Nocturnal Dipping(Baseline through 2 years)
- Baseline Left Ventricular Geometry Classification(Baseline)
- Change in Left Ventricular Geometry Classification(Baseline through 2 years)
- Change in Left Ventricular Systolic Function(Baseline through 2 years)
- Change in Ambulatory Hypertension(Baseline through 2 years)
- Change in Relative Left Ventricular Wall Thickness(Baseline through 2 years)
- Change in Elevated Relative Left Ventricular Wall Thickness(Baseline through 2 years)
- Change in Left Ventricular Diastolic Function(Baseline through 2 years)
- Change in Urine Protein/Creatinine Ratio(Baseline through 2 years)
- Change in Fractional Excretion of Urine Uric Acid(Baseline through 2 years)
- Baseline Obesity(Baseline)
- Baseline Urine Protein/Creatinine Ratio(Baseline)
- Baseline Proteinuria(Baseline)
- Change in Proteinuria(Baseline through 2 years)
- Baseline Elevated Urine Sodium Concentration(Baseline)
- Baseline Urine Uric Acid Per Glomerular Filtration Rate(Baseline)
- Change in Serum Fibroblast Growth Factor 23 Level(Baseline through 2 years)
- Change in Disordered Eating(Baseline through 2 years)
- Change in Food Insecurity(Baseline through 2 years)
- Baseline Elevated Urine Sodium/Potassium Ratio(Baseline)
- Change in Elevated Urine Sodium/Potassium Ratio(Baseline through 2 years)
- Low Estimated Glomerular Filtration Rate(Through study completion up to 2 years)
- Baseline Serum Fibroblast Growth Factor 23 Level(Baseline)
- Baseline Food Insecurity(Baseline)
- Baseline Transportation Stress(Baseline)
- Change in Urine Uric Acid/Creatinine Ratio(Baseline through 2 years)
- Baseline Fractional Excretion of Urine Uric Acid(Baseline)
- Baseline Urine Fibroblast Growth Factor 23 Level(Baseline)
- Baseline Dietary Sodium Intake(Baseline)
- Baseline Disordered Eating(Baseline)
- Baseline Financial Stress(Baseline)
- Change in Financial Stress(Baseline through 2 years)
- Change in Transportation Stress(Baseline through 2 years)