Terlipressin infusion for prevention of vasoplegic syndrome in patients treated with ARBs undergoing CABG

Not Applicable

• Conditions: Circulatory System; vasoplegic syndrome, coronary artery bypass graft surgery

• Registration Number: PACTR201804003249274
• Lead Sponsor: Ain Shams University Hospitals

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-03-25
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

patients on angiotensin II receptor antagonist losartan for at least 4 weeks before operation
normal or mild impairment of left ventricular function (EF ¿ 40 by transthoracic echocardiography).

Exclusion Criteria

Patients with a critical preoperative state were excluded from the study, including patients with intractable ventricular arrhythmias, previous aborted sudden cardiac death, preoperative mechanical ventilation, preoperative use of inotropes, preoperative use of intra-aortic balloon counter-pulsation, recent myocardial infarction. Patients with previous cardiac surgery, associated valvular heart disease, chronic lung disease, extra-cardiac arteriopathy, moderate to severe renal impairment were also excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of vasoplegic syndrome

Secondary Outcome Measures

Name	Time	Method
inotropic score ;vasopressor dependency index ;Hemodynamic parameters: mean arterial blood pressure, central venous pressure, Cardiac index, systemic vascular resistance index.