Outpatient Terlipressin Infusion for the Treatment of Refractory Ascites.

Phase 2

Completed

• Conditions: Ascites; Portal Hypertension; Diuretic refractory ascites; Cirrhosis; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12616000321448
• Lead Sponsor: Paul Gow

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-03-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

Inclusion criteria were refractory ascites secondary to cirrhosis requiring at least fortnightly large volume paracentesis and age greater than 18. It was also necessary for patient’s to have a stable therapeutic paracentesis frequency for at least 3 months.

Exclusion Criteria

Exclusion criteria were: acute coronary syndrome within the past 6 months of enrolment or ongoing angina, prior intolerance to terlipressin, spontaneous bacterial peritonitis in the last 1 month, hepatic vein thrombosis or acute portal vein thrombosis, change in the dose of diuretics within the 30 days preceding the study or anemia with a hemoglobin below 70 mg/dl. The study was approved by the local Human Research Ethics Committee (HREC) and all patients provided written informed consent to participate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified