NCT01741584已完成不适用
Effects of Physical Activity on the Brain in Parkinson's Disease (PD)
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- UPDRS motor score
研究概览
简要总结
The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •UPDRS <15
- •L-DOPA responsive
- •<5 yrs since diagnosis
排除标准
- •severe other diseases
- •MMSE < 26
- •treatment with psychiatric medication
研究组 & 干预措施
stationary bike exercise
Experimental
6 months of exercise (60% of anaerobic threshold)
干预措施: stationary bike exercise (Behavioral)
aerobic
Placebo Comparator
6 months of exercise <30% anaerobic threshold
干预措施: aerobic (Behavioral)
结局指标
主要结局
UPDRS motor score
时间窗: Prior to intervention and after 6 months of intervention
次要结局
- Cognitive Function based on neuropsychological test-performance(Prior to intervention and after 6 months of intervention)
- Plasma biomarkers(Prior to intervention and after 6 months of intervention)
- Functional/Structural brain changes(Prior to intervention and after 6 months of intervention)
研究者
Agnes Flöel
Prof. Dr. med. Agnes Floeel
Charite University, Berlin, Germany
研究点 (1)
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