跳至主要内容
临床试验/NCT01629030
NCT01629030Unknown不适用

Risk Factors of Sternal Wound Infection After Coronary Artery Bypass Graft

Samsung Medical Center1 个研究点 分布在 1 个国家目标入组 1,850 人开始时间: 2012年6月最近更新:
适应症

试验速览

阶段
不适用
入组人数
1,850
试验地点
1
主要终点
postoperative surgical wound infection

研究概览

简要总结

The investigators are trying to evaluate the performance of neutrophil and lymphocyte counts as a risk factor of deep sternal wound infection after coronary artery bypass graft surgery.

详细描述

Deep sternal wound infection after coronary artery bypass graft is a very dangerous complication as it prolongs hospital stay, increase morbidity and mortality, and increase cost of care.

As a risk factor of surgical site infection, risk index reported by NNIS (national nosocomial infection surveillance), Euroscore, or Society of thoracic surgeon risk score are currently used. However, as various performances are reported regarding these index or scoring systems, and many factors are needed for these index or scoring system, there is a need to develop a more simple risk factor with better performance. We focused on the differential blood cell count, as the neutrophil and lymphocyte count are related to the degree of surgical invasion, and inflammatory response. Previous studies reported that the neutrophilia or lymphopenia is related to postoperative infection. Therefore, we are trying to evaluate the performance of preoperative or postoperative the blood cell differential count as a risk factor for sternal wound infection after coronary artery bypass surgery.

研究设计

研究类型
Observational
时间视角
Retrospective

入排标准

年龄范围
20 Years 至 90 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Those underwent coronary artery bypass graft surgery with median sternotomy in Samsung Medical Center during the period of January 2008 and December 2011.

排除标准

  • Those underwent coronary artery bypass graft surgery with mini-thoracotomy
  • Those with insufficient study data recognized by electronic medical record

结局指标

主要结局

postoperative surgical wound infection

时间窗: within first week after the end of coronary artery bypass graft surgery

postoperative surgical wound infection within first week after the end of coronary artery bypass graft surgery, classified as a superfical or deep sternal wound infection

次要结局

  • preoperative total leukocyte count(1 day before surgery)
  • preoperative neutrophil count(1 day before surgery)
  • preoperative EuroScore(1 day before surgery)
  • postoperative lymphocyte count(2 hour after the end of surgery)
  • preoperative NNIS risk index(1 day before surgery)
  • preoperative lymphocyte count(1 day before surgery)
  • postoperative neutrophil count(2 hour after the end of surgery)
  • Preoperative STS(1 day before surgery)
  • postoperative total leukocyte count(2 hour after the end of surgery)
  • the incidence of surgical reopen with surgical wound infection(within 1 month after surgery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Sangmin M. Lee

Professor

Samsung Medical Center

研究点 (1)

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