Effects of Dronabinol (Oral THC) on Cannabis Use
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Marijuana Self-administration - Progressive Ratio
研究概览
简要总结
Study participants received dronabinol (0, 120mg/day and 240mg/day) for 12 consecutive days in a randomized order. During each dronabinol maintenance period they were able to self-administer active or placebo cannabis using either a progressive ratio schedule or choice between cannabis and monetary alternative.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Current use of marijuana
- •Able to give informed consent
排除标准
- •Daily use of psychoactive medication
- •Current Axis I psychiatric disorder other than dependence on cannabis or nicotine, or abuse of drugs or alcohol
- •Women who are pregnant, breast feeding, or planning to become pregnant within the next 3 months
- •Those seeking treatment for cannabis-related problems or using cannabis under the guidance of a physician for a medical disorder
- •Uncontrolled or unstable cardiovascular disease
- •Allergy to sesame oil
研究组 & 干预措施
Low Dose Dronabinol, High Dose Dronabinol, and placebo
Participants were administered dronabinol (0 mg/day, 120mg/day and 240mg/day) for 12 days each in a random order
干预措施: Dronabinol 120mg/day (Drug)
Low Dose Dronabinol, High Dose Dronabinol, and placebo
Participants were administered dronabinol (0 mg/day, 120mg/day and 240mg/day) for 12 days each in a random order
干预措施: Placebo (Drug)
Low Dose Dronabinol, High Dose Dronabinol, and placebo
Participants were administered dronabinol (0 mg/day, 120mg/day and 240mg/day) for 12 days each in a random order
干预措施: Dronabinol 240mg/day (Drug)
结局指标
主要结局
Marijuana Self-administration - Progressive Ratio
时间窗: 12-day Dronabinol maintenance period
Participants will be able to self-administer cannabis cigarettes (weighing about 0.8 grams and with about 6% THC) under a progressive ratio schedule. The number of progressive ratios completed (and thus, cannabis cigarettes consumed) is the primary study endpoint
Marijuana Self-administration - Drug Vs Money Choice
时间窗: 12-day Dronabinol maintenance period
Participants will be able to self-administer cannabis cigarettes (weighing about 0.8 grams and with about 6% THC) in 5 discrete choices each day between one cannabis cigarette and $1. The number of cannabis cigarettes chosen (and subsequently self-administered) is the primary study endpoint
次要结局
未报告次要终点