Exercise Training, CACs, and Vascular Function in Older Veterans With IGT (Impaired Glucose Tolerance)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Baltimore VA Medical Center
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Endothelial progenitor cell number
Study Overview
Brief Summary
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age 50-80
- •Non-smoker
- •If woman, postmenopausal >1 year
Exclusion Criteria
- •History of heart disease or stroke
- •Poorly controlled hypertension or dyslipidemia
- •Kidney or Liver diseases
Arms & Interventions
T2DM
Type 2 Diabetes Mellitus
Intervention: Aerobic Exercise Training (Other)
IGT
Impaired Glucose Tolerance
Intervention: Aerobic Exercise Training (Other)
NGT
Normal Glucose Tolerance
Intervention: Aerobic Exercise Training (Other)
Outcomes
Primary Outcomes
Endothelial progenitor cell number
Time Frame: 6-month
Skeletal muscle capillarization
Time Frame: 6-month
Endothelial progenitor cell number
Time Frame: Baseline
Skeletal muscle capillarization
Time Frame: Baseline
Secondary Outcomes
- Cardiorespiratory Fitness(6-month)
- Cardiorespiratory Fitness(Baseline)
Investigators
Steven J. Prior, Ph.D.
Assistant Professor
Baltimore VA Medical Center