Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Exercise capacity
研究概览
简要总结
Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on
- circulating VEGF-A
- muscle growth and function
- Myostatin
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 40-75 years
- •Advanced NSCLC
- •Eastern Cooperative Oncology Group performance status of 0 or 1
- •Targeted therapy for at least 8 weeks
- •Stable condition
排除标准
- •Severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise
- •Do not understand the verbal or written instructions
研究组 & 干预措施
Exercise training
Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer.
干预措施: Exercise training (Behavioral)
Control group
Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital.
干预措施: Usual care (Other)
结局指标
主要结局
Exercise capacity
时间窗: 8 weeks after the start of the intervention
Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS
次要结局
- Imaging of muscle(8 weeks and 16 weeks after the start of the intervention)
- Analysis of venous blood sample(8 weeks andd 16 weeks after the start of the intervention)
- Quality of life(baseline, 8 weeks, 16 weeks)
- Exercise capacity(16 weeks after the start of the intervention)
- Muscle function(8 weeks and 16 weeks after the start of the intervention)
- Physical activity(8 weeks andd 16 weeks after the start of the intervention)
- Dietary intake(8 weeks andd 16 weeks after the start of the intervention)
- Body composition(8 weeks andd 16 weeks after the start of the intervention)