Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes

Not Applicable

Active, not recruiting

• Conditions: Type 2 Diabetes Mellitus

• Registration Number: NCT01176578
• Lead Sponsor: Baltimore VA Medical Center

Brief Summary

The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-08-05
• Study First Submitted QC: 2010-08-05
• Study First Posted: 2010-08-06
• Study Start: 2011-07
• Primary Completion: 2021-12-31
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-20
• Last Update Posted: 2024-08-22
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Age 50-80
• Non-smoker
• If woman, postmenopausal >1 year

Exclusion Criteria

• History of heart disease or stroke
• Cancer
• Poorly controlled hypertension or dyslipidemia
• Kidney or Liver diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Endothelial progenitor cell number	6-month
Skeletal muscle capillarization	6-month

Secondary Outcome Measures

Name	Time	Method
Cardiorespiratory Fitness	6-month

Trial Locations

Locations (1)

Baltimore VA Medical Center; 🇺🇸 Baltimore, Maryland, United States