Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients

Not Applicable

Completed

• Conditions: Non-small-cell Lung Cancer
• Interventions: Behavioral: Exercise training; Other: Usual care

• Registration Number: NCT01136083
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on

1. circulating VEGF-A

2. muscle growth and function

3. Myostatin

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-05-10
• Study First Submitted QC: 2010-06-02
• Study First Posted: 2010-06-03
• Study Start: 2010-09
• Primary Completion: 2011-08
• Status Verified: 2011-11
• Study Completion: 2012-08
• Last Update Submitted: 2013-08-12
• Last Update Posted: 2013-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age 40-75 years
• Advanced NSCLC
• Eastern Cooperative Oncology Group performance status of 0 or 1
• Targeted therapy for at least 8 weeks
• Stable condition

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Exclusion Criteria

• Severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise
• Do not understand the verbal or written instructions

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise training	Exercise training	Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer.
Control group	Usual care	Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital.

Primary Outcome Measures

Name	Time	Method
Exercise capacity	8 weeks after the start of the intervention	Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS

Secondary Outcome Measures

Name	Time	Method
Imaging of muscle	8 weeks and 16 weeks after the start of the intervention	Measured by MRS
Analysis of venous blood sample	8 weeks andd 16 weeks after the start of the intervention	Analysis of circulating VEGF-A and myostatin
Quality of life	baseline, 8 weeks, 16 weeks	Measured by questionnaire
Exercise capacity	16 weeks after the start of the intervention	Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS
Muscle function	8 weeks and 16 weeks after the start of the intervention	Isokinetic muscle strength and endurance with Biodex
Physical activity	8 weeks andd 16 weeks after the start of the intervention	Measured with 7-day recall questionnaire
Dietary intake	8 weeks andd 16 weeks after the start of the intervention	Measured with 24-hour recall questionnaire
Body composition	8 weeks andd 16 weeks after the start of the intervention	Body mass index calculated with body weight and height; % body fat abd free-fat mass with BIA

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei City, Taiwan