Evaluation of the Venous Excess Ultrasound Score (VExUS) After Circulating Volume Modification in Children.

Recruiting

• Conditions: Blood Volume Expansion

• Registration Number: NCT06695546
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

Venous overload has an impact on peripheral organ perfusion and on the short- and long-term prognosis of intensive care patients. The VExUS ultrasound score is a new tool whose parameters can be used to estimate this impact. This score was initially evaluated and validated on an adult population. ) In children, there is only one study looking at the use and applicability of this VExUS score, highlighting its feasibility in a paediatric population, as well as a possible correlation between elevated central venous pressure and altered renal Doppler (one of the score's components).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-11-08
• Study First Submitted QC: 2024-11-15
• Study First Posted: 2024-11-19
• Study Start: 2024-12-10
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-07
• Last Update Posted: 2025-04-10
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

Children aged between 1 and 18 years, receiving extrarenal purification with UF > 10 ml/kg, bleeding > 10 ml/kg or vascular filling > 10 ml/kg

Exclusion Criteria

• Refusal of the patient or opposition of one or both holders of parental authority.
• Minors with parental authority.
• Ultrafiltration time > 6h.
• Curarized patient, known abnormality of the hepatorenal venous network.
• Patient agitated or poor tolerance of the examination.
• Parents under court protection, guardianship or curatorship.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in VExUS score	10 minutes before en after the procedure of extrarenal purification, bloodletting or vascular filling	The correlation between ultrasound measurement of the VExUS score and the change in blood volume induced by extrarenal purification, bloodletting or vascular filling is studied. Ultrasound is performed before and after the procedure, each measure 3 times in succession, to establish the score.

Trial Locations

Locations (1)

CHU Toulouse; 🇫🇷 Toulouse, France