NCT04564378已完成不适用
Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Association Between Fuchs endothelial Corneal Dystophy Severity and Estrogen Exposure
研究概览
简要总结
This study is being done to discover if there is a link between estrogen exposure and the severity of Fuchs Endothelial Corneal Disease. We are trying to understand if the decrease in estrogen levels in post-menopausal women may be a reason why FECD is seen more often in women than men.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals with FECD grade 1-2/7 (mild) or 5-6/7 (severe) in one or both eyes
- •Phakic and pseudophakic individuals will be included. Pseudophakic patients must have evidence of routine cataract surgery (posterior chamber intraocular lens in-the-bag without clinical evidence of damage to any intraocular structures).
排除标准
- •Females are excluded if not post-menopause.
- •Pseudophakic patients with a history of complex cataract surgery or other intraocular surgery (e.g. have an anterior chamber lens, sulcus lens, or poorly positioned posterior chamber lens, aphakia, iris damage, glaucoma surgery) will be excluded due to risk of iatrogenic damage to the corneal endothelium.
结局指标
主要结局
Association Between Fuchs endothelial Corneal Dystophy Severity and Estrogen Exposure
时间窗: 5 years
Difference in measures of estriadiol exposure between individuals with mild vs. severe FECD
次要结局
未报告次要终点
研究者
Sangita Patel
Assistant Professor
State University of New York at Buffalo
研究点 (1)
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