OCT in Fuchs' Dystrophy
Recruiting
- Conditions
- Fuchs DystrophyPseudophakic Bullous Keratopathy
- Registration Number
- NCT04258787
- Lead Sponsor
- Oregon Health and Science University
- Brief Summary
This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Damaged or diseased corneal endothelium from Fuchs' or PBK
- Willingness to commit to required study visits
Exclusion Criteria
- Prior Endothelial Keratoplasty (EK) or any other surgery except uncomplicated cataract surgery
- Presence of a condition that increases the probability for treatment failure (e.g., heavily vascularized cornea, uncontrolled uveitis)
- Other primary endothelial dysfunction conditions (e.g., posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy, iridocorneal endothelial syndrome)
- Central sub-epithelial or stromal scarring that could impact post-operative clarity assessment
- Peripheral anterior synechiae in the angle greater than 3 clock hours
- Hypotony
- Uncontrolled glaucoma
- Visually significant optic nerve or macular pathology
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Corneal Stromal Edema/Haze up to 2 years OCT will be used to measure corneal stromal edema/haze (in microns) in participants with Fuchs' or PBK
Corneal Epithelial Edema/Haze up to 2 years OCT will be used to measure corneal epithelial edema/haze (in microns) in participants with Fuchs' or PBK
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oregon Health & Science University
🇺🇸Portland, Oregon, United States