Optical Coherence Tomography Angiography Findings After Intravitreal Ranibizumab in Patients With Coats Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Study of retinal and vascular features in Coats disease after intravitreal injections of Ranibizumab
研究概览
简要总结
This study evaluates the retinal and vascular features in patients affected by Coats disease under the effects of Ranibizumab intravitreal injections using optical coherence tomography and optical coherence tomography angiography
详细描述
Coats disease is an idiopathic retinal vascular disorder, occurs in young males, and is characterized by retinal telangiactasias, numerous yellowish exudates in the subretinal space, macular edema, hemorrhages and, in advanced end-stage, by exudative retinal detachment.
Ranibizumab is a vascular endothelial growth factor antagonist represent an efficacy treatment acting on vascular hyperpermeability. The optical coherence tomography and optical coherence tomography angiography represent novel and non-invasive diagnostic techniques that allow a detailed analysis of retinal and vascular features. The study evaluates the changes in optical coherence tomography and optical coherence tomography angiography parameters at baseline and after three monthly injections of Ranibizumab in Coats disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •age older than 18 years
- •diagnosis of Coats disease
- •treatment-naïve with Ranibizumab
- •absence of other vitreoretinal and vascular retinal diseases
- •absence of diabetes
排除标准
- •age younger than 18 years
- •No diagnosis of Coats disease
- •previous treatments with Ranibizumab
- •presence of vitreoretinal and vascular retinal diseases
- •presence of diabetes
结局指标
主要结局
Study of retinal and vascular features in Coats disease after intravitreal injections of Ranibizumab
时间窗: Three months
The effectiveness of Ranibizumab injections for treating Coats disease using optical coherence tomography angiography (OCTA) The parameters analyzed by OCTA were: retinal vessel density (%), choriocapillaris vessel density (%)
次要结局
未报告次要终点
研究者
Gilda Cennamo
Principal Investigator
Federico II University