Post Surgical Comparison of expression of Biomarkers in Gingival crevicular fluid and blood for dental implant patients for assessment of wound healing
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Expression of genes
研究概览
简要总结
This study investigates expression of biomarkers in Gingival Crevicular fluid (GCF) and Blood to not only assess healing progress but also inform about the prognosis of the procedure in a non-invasive way. By analyzing and comparing specific biomarkers i.e. IL(A), IL(B) and TNF(A) in both GCF and blood, this study aims to establish reliable indicators of successful healing after placement of dental implant This prospective cohort study investigates the association between GCF (gingival Crevicular fluid) biomarkers and peri-implant health in adult patients who have undergone dental implant surgery. For which sample Size is Thirty (30) adult patients to be recruited at Thaimoogambigai Dental College and Hospital, Chennai, India. GCF will be collected from peri-implant sites using standardized protocols. and the collected GCF will be analysed for specific biomarkers using appropriate equipment (armamentarium) for biomarker analysis.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients (18 years or older) who are willing for dental implant surgery -Sufficient bone density and quality for implant placement, confirmed by radiographic examination.
- •Participants willing to adhere to follow-up visits and sample collection procedures.
排除标准
- •Patients with Active systemic diseases (uncontrolled diabetes, autoimmune diseases).
- •Recent antibiotic or anti-inflammatory therapy within the past 4 weeks.
- •History of deleterious habits (smoking/chewing tobacco, consumption of alcohol).
- •Signs of active infection or complications at the implant site.
- •Pregnancy or breastfeeding.
结局指标
主要结局
Expression of genes
时间窗: at baseline, 1 week, 4 weeks
次要结局
未报告次要终点
研究者
Sayantan Bhattacharya
Thaimoogambigai Dental College and Hospital