Comparative evaluation of IL-6 and IL-1 beta levels in Polymethyl Methacrylate (PMMA) milled and 3D printed provisional crowns: A split-mouth study.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- 1). To evaluate the level of IL-6 in gingival crevicular fluid(GCF) just before tooth preparation(baseline) and after cementation of CAD/CAM milled and 3D printed PMMA resin provisional crown on mandibular first molar at 2 week and 6 week .
研究概览
简要总结
Gingival crevicular fluid contains various biomarkers, which are associated with periodontal inflammation and tissue degradation. Among the various biomarkers present in GCF, pro-inflammatory cytokines such as Interleukin-6 and Interleukin-1 beta play a pivotal role in the host immune response and appears early in GCF.Numerous studies have explored gingival biomarker levels in relation to permanent crowns, there is limited research on how provisional crowns influence gingival inflammation and biomarker expression.Literature is scanty on effect of provisional crowns fabricated using milled or PMMA on periodontal health. Therefore this study is designed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients requiring bilateral posterior mandibular complete crowns.
- •2.Teeth selected for temporary CAD/CAM milled and printed crown preparation should be restorable with a minimum crown to root ratio of at least 1:
- •3.Patients with good oral hygiene and periodontal status.
- •4.Patients with full complement of teeth .
- •5.Patients who will be available for the required follow up period.
- •6.Patients giving positive informed consent.
排除标准
- •1.Patients with developmental defects of enamel and dentin 2.Patients with systemic disease(e.g., diabetic mellitus,,hypertension,cancer,sjogren,’s syndrome etc.) 3.Habitual tobacco smokers or chewers.
- •4.Untreated gingival or periodontal disease 5.Parafunctional habits like bruxism, clenching.
- •6.Temporomandibular joint disorders.
- •7.Patients with fluorosis, calcium metabolic disorders, osteoporosis.
- •8.Patients having malocclusion .
- •9.Pregnant and breastfeeding women.
结局指标
主要结局
1). To evaluate the level of IL-6 in gingival crevicular fluid(GCF) just before tooth preparation(baseline) and after cementation of CAD/CAM milled and 3D printed PMMA resin provisional crown on mandibular first molar at 2 week and 6 week .
时间窗: before preparation,after2 weeks and 6 weeks
2). To evaluate the level of IL-1 beta in gingival crevicular fluid(GCF) just before tooth preparation(baseline) and after cementation of CAD/CAM milled and 3D printed PMMA resin provisional crown on mandibular first molar at 2 week and 6 week.
时间窗: before preparation,after2 weeks and 6 weeks
次要结局
- 1). To compare the level of IL-6 in gingival crevicular fluid before tooth preparation (baseline)and after cementation of CAD-CAM milled and 3D printed provisional restoration on mandibular first molar at 2week and 6 week interval.(2). To compare the level of IL-1 beta in gingival crevicular fluid before tooth preparation (baseline)and after cementation of provisional restoration on mandibular first molar at 2week and 6 week interval.)
研究者
Krishna vk
CDER,AIIMS NEW DELHI.