The NutriNet-Santé Study

Recruiting

• Conditions: Diet, Food, and Nutrition; Diseases Category; Anthropometry; Cohort Studies; Mortality; Humans; Exercise; Adult; Internet; Surveys and Questionnaires

• Registration Number: NCT03335644
• Lead Sponsor: University of Paris 13

Brief Summary

The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior.

https://etude-nutrinet-sante.fr/ https://info.etude-nutrinet-sante.fr/en

Detailed Description

NutriNet-Santé is a large-scale (n=171,000) web-based cohort coordinated by EREN, launched in France in 2009 to investigate nutrition and health relationships. All required ethics authorisations have been obtained (listed here). NutriNet-Santé participants regularly fill questionnaires through a dedicated and secure website, providing extensive, high-quality nutritional and non-nutritional data, including repeated data on socio-demographics and lifestyle (yearly), anthropometrics (every 6 months), dietary intake (every 6 months), physical activity (IPAQ questionnaire, yearly)5 and health status (every 6 months). NutriNet-Santé is characterised by a very detailed and up-to-date assessment of nutritional exposure and dietary behaviours. Usual dietary intakes are assessed at baseline and every 6 months thereafter through a series of 3 non-consecutive randomly assigned 24h dietary records. Daily energy, alcohol, micro- and macronutrient intakes are calculated using the published NutriNet-Santé food composition database (\>3,500 generic items). All major health events (e.g., cancers, cardio- and cerebrovascular diseases) are reported by the participants and validated by an expert committee of physicians based on medical records, and/or retrieved from the French National Health Insurance medico-administrative databases to limit potential reporting bias. In turn, mortality data are obtained from the exhaustive French National Mortality Registry (CépiDC). The number of incident events already registered is as follows: 4,200 cancers and 1,240 deaths. A sub-sample of the cohort (n=20,000) provided blood and urine samples, currently stored at -80°C in EREN's biobank.

Study Timeline

• Study Start: 2009-05-11
• Study First Submitted: 2017-10-11
• Study First Submitted QC: 2017-11-02
• Study First Posted: 2017-11-08
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-22
• Last Update Posted: 2021-07-26
• Primary Completion: 2029-05-11
• Study Completion: 2029-05-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 170000

Inclusion Criteria

• aged over 15 years
• access to internet

Exclusion Criteria

• aged under 15 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CVD using health questionnaire and/or the dedicated website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
type 2 diabetes using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
migraine using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
cancers using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
depression using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
quality of life using the SF-36 questionnaire	every 6 months after registration, up to 10 years of follow-up	self reported
Mortality	continuously updated	CepiDC exhaustive national registry
SARSCOV-2 (Covid 19) infection	regular update for a subsampe of the cohort from 2020	serology + questionnaires on symptoms
hypertension using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
metabolic syndrome using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
cognitive decline using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
multi-morbidity (mental and physical health)	continuous update	combination of previsously listed mental and physical health outcomes
rheumatoid arthritis using health questionnaire and/or the website for declaration of major health events	every 6 months after registration, up to 10 years of follow-up	self reported
Weight using anthropometric questionnaire	every year after registration, up to 10 years of follow-up	self reported
Height using anthropometric questionnaire	every year after registration, up to 10 years of follow-up	self reported
Mental health (incl. anxious disorders, sleep disorders, addictive behaviors, eating disorders)	repeatedly during followup	self reported though validated scales and/or questionnaires

Trial Locations

Locations (1)

EREN; 🇫🇷 Bobigny, Seine Saint Denis, France