Research on Nutritional Risk Indexes and Inflammatory Indicators in Postoperative Complications and Prognosis of Epithelial Ovarian Cancer Patients

Completed

• Conditions: Epithelial Ovarian Cancer

• Registration Number: NCT06483399
• Lead Sponsor: Qinglei Gao

Brief Summary

The goal of this observational study is to explore the influence and predictive significance of nutritional risk indicators and inflammatory indicators on postoperative complications and prognosis of patients with epithelial ovarian cancer (EOC). The main question it aims to answer is:

Can preoperative nutritional risk and inflammatory indexes predict postoperative complications? Do preoperative nutritional risk and inflammatory indexes better predict the prognosis of patients with epithelial ovarian cancer? Which index is the best predictor of postoperative complications or prognosis for patients?

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2023-02-28
• Study Completion: 2023-02-28
• Status Verified: 2024-06
• Study First Submitted: 2024-06-24
• Study First Submitted QC: 2024-06-27
• Last Update Submitted: 2024-06-27
• Study First Posted: 2024-07-03
• Last Update Posted: 2024-07-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 1108

Inclusion Criteria

1. histologically confirmed primary epithelial ovarian, peritoneal, and fallopian tube cancers.
2. patients received comprehensive staged surgery or debulking surgery.
3. available data of laboratory examination within 7 days before the surgery.

Exclusion Criteria

1. borderline ovarian tumor.
2. receipt of neoadjuvant chemotherapy.
3. presence of other conditions influencing laboratory data, like hepatitis, kidney disease, autoimmune diseases, infectious diseases, blood disease, etc.
4. concurrent cancer in other organs.
5. absence of surgery or biopsy only.
6. multiple staged surgeries.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Progression-free survival	From the date the patient diagnosed with primary ovarian, fallopian tube, or peritoneal cancer to the date of disease progression or death or last follow-up, whichever occurred first, assessed up to 100 months.	Interval between first diagnosis and first recurrence, death, or last follow-up
Postoperative Complications	Within 30 days after surgery	Surgical complications within 30 days after comprehensive staging or cytoreductive surgery recorded according to the Clavien-Dindo grading system
Overall survival	From the date the patient diagnosed with primary ovarian, fallopian tube, or peritoneal cancer to the date of death or last follow-up, whichever occurred first, assessed up to 100 months.	Interval between first diagnosis and death, or last follow-up