Clinical and microbiological evaluation of different implant surface decontaminating procedures in the surgical treatment of peri-implantitis; a double blind placebo controlled randomized clinical study - Implant surface decontamination in peri-implantitis treatment

niversitair Medisch Centrum Groningen0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年5月6日

适应症

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•1) The patient is >= 18 years of age;
•2) The patient has at least one endosseous implant in the oral cavity with clinical and radiographical signs of peri-implantitis. Peri-implantitis is defined as a loss of marginal bone >= 2 mm as compared to a fixed reference point on the dental implant, in combination with bleeding and/or suppuration on probing and a peri-implant probing depth >= 5 mm;
•3) The implants have been exposed to the oral environment for at least two years;
•4) The patient is capable of understanding and giving informed consent.

•1) Medical and general contraindications for the surgical procedures;
•2) A history of local radiotherapy to the head and neck region;
•3) Pregnancy and lactation;
•4) Diabetes;
•5) Systemic use of antibiotics during the last 2 months;
•6) Long-term use of anti-inflammatory drugs;
•7) Incapability of performing basal oral hygiene measures as a result of physical or mental disorders;
•8) Active, uncontrolled periodontal pathology of the remaining dentition;
•9) Local use of antibiotics or use of other anti-septic / antimicrobial therapies in the oral cavity during the last 2 months;
•10) Bruxism;
•11) Implants placed in skin grafted areas;
•12) Implants with bone loss due to other reasons than bacterial infection (e.g. loose screw, inadequate positioning of the implant);
•13) Implants with bone loss exceding 2/3 of the length of the implant or implants with bone loss beyond the transverse openings in hollow implants;
•14) Implant mobility;
•15) Implants at which no postition can be identified where proper probing measurements can be performed;
•16) Previous surgical treatment of the peri-implantitis lesions;
•17) Previous non-surgical treatment of the peri-implantitis lesions during the last 6 months (scaling or curretage).

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