Dose Response Bioavailability of Coffee and Green Tea Antioxidants in Humans

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Coffee; Other: Green tea

• Registration Number: NCT01089920
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

Coffee and green tea are 2 widely consumed beverages. Both contain polyphenol antioxidant compounds (chlorogenic acids for coffee and catechins for tea). The bioavailability of catechins is somewhat known and has been referenced in the literature. However, bioavailability data from tea infusion is non-existent, even though it reflects better how consumers drink this beverage. In addition, bioavailability of coffee chlorogenic acids is less understood and no dose response study has been reported so far in the literature. Thus, there is a great need to understand and reinforce our knowledge on the bioavailability of coffee and tea polyphenol compounds.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09
• Primary Completion: 2010-02
• Study Completion: 2010-02
• Study First Submitted: 2010-03-18
• Study First Submitted QC: 2010-03-18
• Study First Posted: 2010-03-19
• Status Verified: 2014-06
• Last Update Submitted: 2014-06-04
• Last Update Posted: 2014-06-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• 18 - 65 years, male and female
• Healthy as determined by the medical questionnaire and the medical visit
• Normal weight: BMI 18 - 25
• Coffee drinkers with an average consumption of 2-5 cups per day
• Having given informed consent

Exclusion Criteria

• Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer
• Have had a gastrointestinal surgery, except appendicectomy
• Difficulty to swallow
• Have a regular consumption of medication
• Have taken antibiotic therapy within the last 6 months
• Alcohol consumption > 2 units a day
• Smokers (more than 5 cigarettes per day)
• Have given blood within the last 3 weeks
• Volunteers who cannot be expected to comply with treatment
• Currently participating or having participated in another clinical trial during the last 3 weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low dose coffee	Coffee	Low dose of polyphenols from soluble coffee
High dose green tea	Green tea	High dose of green tea polyphenols from infusion
High dose coffee	Coffee	High dose of polyphenols from soluble coffee
Medium dose coffee	Coffee	Medium dose of polyphenols from soluble coffee
Medium dose green tea infusion	Green tea	Medium dose of green polyphenols from infusion
Low dose green tea infusion	Green tea	low dose of polyphenols from an infusion of green tea

Primary Outcome Measures

Name	Time	Method
Compare plasma Area under the curve (AUC) of highest and lowest dose of coffee for chlorogenic and phenolic acid metabolites	Measurements done over 24h after ingestion

Secondary Outcome Measures

Name	Time	Method
Compare Area under the curve (AUC), Maximum plasma concentration (Cmax), Time to reach maximum plasma concentration (Tmax) and half-life (T1/2) of all three doses of coffee for chlorogenic and phenolic acid metabolites	Measurements done over 12h after ingestion
Compare AUC, Cmax, Tmax and T1/2 of all three doses of green tea for catechin metabolites	Measurements done over 12h after ingestion

Trial Locations

Locations (1)

Nestle Research Center; 🇨🇭 Lausanne, Switzerland