Coffee-bioavailability-cardiovascular health
- Conditions
- Oxidative stress, inflammation, endothelial function, blood pressure and lipid profile
- Registration Number
- RPCEC00000168
- Lead Sponsor
- (Vidarium) Vidarium, research center on nutrition health and wellness
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 75
1. Aged = 18 and = 60 years
2. Body mass index (BMI) between 18.8 kg/m2 and 30 kg/m2 up.
3. Habitual coffee drinkers: consumption in the last year of three or more cups / day.
4. No smokers.
5. No highly competitive sportspeople (subjects with a sedentary physical activity, mild or moderate will be included, in no case exceeding 10 hours per week of training).
6. No history and / or diagnosis of chronic diseases (heart attack, hypertension, congestive heart failure, stroke, arrhythmia, dyslipidemia, diabetes mellitus, cancer, chronic renal failure, hepatic dysfunction, hypothyroidism, insomnia, duodenal ulcer, gastritis, malabsorption syndrome, dysautonomia, sleep disturbances and psychiatric disorders).
7. No consumption of drugs: Hypolipidemic agent, antioxidant supplements, anticonvulsants, anti-inflammatories, steroids, psychiatric drugs, hormone replacement therapy.
8. With a maximum of 10 alcohol drinks per week for women and 15 for men.
9. Having a work schedule between 7.00 am and 6.00 pm Monday to Friday and not have to leave the institution during the study.
1. Women who are pregnant or breastfeeding.
2. Vegetarians.
3. Subjects with secondary symptoms to coffee consumption.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma levels of caffeic acid and ferulic acid (quantitative determination in nmol/L by chromatography). Measurement time: at baseline, 1 hour after the first consumption, 8 weeks after the inclusion. <br>Total antioxidant capacity (umol-equ-TROLOX/L plasma values measured by FRAP and TRAP methods). Measurement time: at baseline, 1 hour after the first consumption, 8 weeks after the inclusion. <br>Delay in LDL oxidation ((lipid peroxidation), LDL oxidation Lag time in seconds). Measurement time: at baseline, 8 weeks after the inclusion.<br>
- Secondary Outcome Measures
Name Time Method