Short- and Long-term Health Consequences of Workers During Consecutive Days of Heat Stress

Not Applicable

Completed

• Conditions: Fatigue; Heat Stress
• Interventions: Other: Hot Dry

• Registration Number: NCT05302674
• Lead Sponsor: State University of New York at Buffalo

Brief Summary

The purpose of this study is to measure fatigue and indicators of acute kidney injury during consecutive days of work in a hot environment.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-11
• Study First Submitted QC: 2022-03-26
• Study First Posted: 2022-03-31
• Study Start: 2022-04-01
• Primary Completion: 2024-03-14
• Study Completion: 2024-03-14
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-14
• Last Update Posted: 2024-06-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy individuals
• Regularly completes aerobic exercise at least 60 min per week

Exclusion Criteria

• History of cardiovascular, metabolic, respiratory, neural, or renal disease
• Hypertensive or tachycardic during the screening visit (Systolic Blood Pressure > 139 mmHg, Diastolic Blood Pressure > 89 mmHg, heart rate > 100 bpm)
• Current tobacco or nicotine use or previous regular use within the past 2 years
• Current or previous musculoskeletal injury limiting physical activity
• Taking medications with known thermoregulatory or cardiovascular effects (e.g., aspirin, beta blockers, diuretics, psychotropics, etc.)
• A positive pregnancy test at any point during the study or currently breastfeeding
• Study physician discretion based on any other medical condition or medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Hot Dry	Hot Dry	The participant will complete four hours of work at a 45:15 work rest cycle in a 98°F (36.7°C) and 20% relative humidity environment.

Primary Outcome Measures

Name	Time	Method
Change from baseline in fatigue	Hour 4	Fatigue will be measured using accelerometry, with the primary variable being jerk, the smoothness or unevenness of movement.
Biomarkers of acute kidney injury	Hour 4	Tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) are biomarkers that have the potential for early prediction of acute kidney injury.

Trial Locations

Locations (1)

Center for Research and Education in Special Environments; 🇺🇸 Buffalo, New York, United States