Retina Microvascularisation and Cardiovascular Heart Disease Prediction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Occurrence of a major cardiovascular event or complication, defined as hospitalization, death from coronary heart disease, hypertension, arteriosclerosis, nonfatal non-procedure-related myocardial infarction, or fatal or nonfatal stroke
研究概览
简要总结
Earlier studies have found that retinal photography could be very useful for evaluating the condition of microcirculation and the risk of cardiovascular diseases in patients. The architectural changes in retinal vascularisation strongly correlates with macrovascular remodeling. Also, recent founding suggests a possible close anatomical parallel between both the macrovascular and the microvascular blood.
Our objectives are to assess (1) in which age and sex subgroups, if any, retinal vascular alteration in arterioles and venules can be predictive for cardiovascular morbidity and mortality; and (2) whether variations in arteriolar or venular caliber will predict better cardiovascular pathogenesis in normal and patient population. If the association between the diameter of the retinal vessels and the risks of cardiovascular disease is verified during this study, the impact on prevention would be enormous. The retinal microvascular change could become a powerful biomarker in the early detection of the cardiovascular pathogenesis and death risk
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 50 to 70 years old (male/female)
- •indication of coronarography within the last 3 month preceding the enrollment
- •Patients with history of stroke, heart failure or arteriosclerosis.
- •At least one of the following risk factors for cardiovascular complication:
- •Hypertension
- •Coronary heart disease (CHD)
- •Structural heart disease
- •Dyslipidemia
排除标准
- •Patients with a permanent pacemaker or ICD
- •Nephrosis or chronic renal failure
- •The study interferes with therapeutic or diagnostic procedures
- •Patients with inability to consent or comply with follow up requirements
- •Patients with glaucoma
- •Patients with any retina degeneration disease vascular age-related macular degeneration or any -retina degeneration disease
- •Patients who are pregnant
结局指标
主要结局
Occurrence of a major cardiovascular event or complication, defined as hospitalization, death from coronary heart disease, hypertension, arteriosclerosis, nonfatal non-procedure-related myocardial infarction, or fatal or nonfatal stroke
时间窗: 2 years
次要结局
- Characterization of any retinal vascular disorders occurring at any time during the study: i. Confirmed by an ophthalmologist examination and either an fundus camera or an mfERGs examination ii. Occurrence of serious ophthalmic event(2 years)
- Correlation with possible cardiovascular event(2 years)
研究者
Bernard Thibault
Cardiologist - Electrophysiologist
Montreal Heart Institute