Finding the biological basis of lost brain connections in Alzheimer*s Disease

Recruiting

Conditions: Alzheimer's disease
mild cognitive impairment
10029305

Registration Number: NL-OMON54226

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 55

Inclusion Criteria

- Clinical diagnosis of mild cognitive impairment due to Alzheimer's Disease
- Abnormal CSF biomarker for aggregated amyloid
- Signed informed consent for Amsterdam Dementia Cohort (ADC) (P2016.061) and
Amsterdam Dementia Biobank (P2017.315)
- Age >=50 years

Exclusion Criteria

- No CSF collection or MRI-imaging at screening at memory clinic
- Clinical diagnosis of dementia or subjective cognitive decline
- Other neurological diagnosis, such as Parkinson*s disease, symptomatic
stroke, mental retardation, brain tumor or infection, likely to be cause of
cognitive impairment
- Major psychiatric disorder, such as psychosis, schizophrenia, depression with
vital signs, severe personality disorder, abuse of alcohol or other substances,
likely to be cause of cognitive impairment
- Use of (oral) anticoagulants or other contraindications for lumbar puncture
- Contraindications for MRI scan (e.g., metal implants, pacemaker)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main predictor: baseline and longitudinal biological processes measured with<br /><br>CSF proteomics.<br /><br>Main endpoints: decline in brain network measures over time compared to<br /><br>baseline.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints:<br /><br>- Decline in cognitive functioning over time compared to baseline as measured<br /><br>with a neuropsychological test battery<br /><br>- Progression to dementia</p><br>