Abnormal patterns of brain connectivity in major depressio

Recruiting

• Conditions: have the blues; mood disorder; 10027946

• Registration Number: NL-OMON38392
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

PATIENTS
Between 18 - 70 years old and able to give voluntary informed consent
Diagnosis of unipolar depression. The diagnosis of depression will be made by the participants* treating psychiatrist/ psychologist and confirmed with the Structured Clinical Interview for DSM-IV (SCID-I).
Severity of the depression: moderate to severe (BDI-II score >=20)
Duration of the depression: longer than 2 months
Are already receiving or will receive in the coming weeks treatment for depression;HEALTHY PARTICIPANTS WITH FAMILY HISTORY OF DEPRESSION
Between 18 - 70 years old
No current or history of major psychiatric illness
A first-degree relative (i.e. father, mother, brother or sister) that has been diagnosed with unipolar depression. This diagnosis needs to be confirmed by the GP, psychologist or psychiatrist of the family member;HEALTHY CONTROLS
Between 18 - 70 years old
No current or history of major psychiatric illness
No family history of major depression

Exclusion Criteria

PATIENTS
Meeting DSM-IV criteria for schizophrenia, schizo-affective disorder, bipolar disorder or an anxiety disorder as a primary diagnosis
Meeting DSM-IV criteria for drug dependence as a primary diagnosis
High suicidal risk (evaluated by the treating clinicians as part of standard therapy procedures)
MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding
Serious medical or neurological illness
Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam
HEALTHY PARTICIPANTS WITH FAMILY HISTORY OF DEPRESSION
Meeting DSM-IV criteria for drug dependence, except caffeine or nicotine
MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding
Serious medical or neurological illness
Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam
HEALTHY CONTROLS
Meeting DSM-IV criteria for drug dependence, except caffeine or nicotine
MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding.
Serious medical or neurological illness
Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in structural T1, DTI, functional resting-state and functional<br /><br>task-related connectivity and effective connectivity between:<br /><br><br /><br>1)depressed patients and healthy controls<br /><br>2)depressed patients and healthy participants with a genetic vulnerability to<br /><br>depression<br /><br>3)healthy controls and healthy participants with a genetic vulnerability to<br /><br>depression<br /><br>4)depressed patients before and after 9 months of treatment<br /><br><br /><br>Correlations between:<br /><br><br /><br>1)severity of depression and functional/anatomical connectivity<br /><br>2)cognitive performance and functional/anatomical connectivity<br /><br>3)treatment success and changes in functional/anatomical connectivity</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>