Effects of transfusion of leucocyte-depleted erythrocytes in cardiac valve surgey on postoperative complications

Not Applicable

Completed

• Conditions: Heart surgery; Surgery

• Registration Number: ISRCTN68522192
• Lead Sponsor: etherlands Heart Foundation (Nederlandse Hartstichting) (Netherlands)

Brief Summary

2004 Results article in https://pubmed.ncbi.nlm.nih.gov/15148271 2005 Other publications in https://pubmed.ncbi.nlm.nih.gov/15943705

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2001-05-01
• Study Start: 2005-12-20
• Last Update Posted: 28 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 496

Inclusion Criteria

Patients undergoing valve surgery (+/- Coronary Artery Bypass Grafting [CABG]).

Exclusion Criteria

1. Patients under 18 years of age
2. Medical indications for leucocyte-depleted erythrocytes
3. Received blood transfusions within previous 3 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
90-days mortality and causes of deaths.

Secondary Outcome Measures

Name	Time	Method
<br> 1. In-hospital mortality<br> 2. 30- and 60-days mortality<br> 3. Onset and type of postoperative infections<br> 4. Onset and type of MODS<br> 5. ICU-stay, hospital-stay and long-term survival<br> 6. Pro-and anti-inflammatory cytokine profile, complement system activation and inflammatory mediators<br> 7. Cost-effective-analysis for the primary outcome<br>