Effects of High intensity Interval Training on CENTRAL hemodynamics at rest and during exercise

Completed

Conditions: Chronic heart failure
left ventricular systolic dysfunction
10019280

Registration Number: NL-OMON37552

Lead Sponsor: Maxima Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

* Written informed consent.
* Systolic heart failure due to ischemic cardiomyopathy (due to one or more myocardial infarction, as confirmed with echocardiography) or dilating cardiomyopathy (no history of myocardial infarction, no proven ischemia, no congenital heart disease en no severe valve disorder)
* Left ventricular ejection fraction (LVEF) * 40% (assessed within 3 months before inclusion by echocardiography, MRI or radionuclear measurement)
* New York Heart Association (NYHA) class II or III
* Optimal medical treatment

Exclusion Criteria

* Myocardial infarction or unstable angina less than 3 months prior to inclusion
* Clinical signs of decompensated heart failure
* Ventricular tachycardia or ischemia during exercise
* Participation in a training program (*2/week) in the last year
* Intracardiac shunts or congenital heart disease limiting exercise capacity
* Orthopaedic, vascular, pulmonary, neuromuscular and other disease limiting exercise capacity in a way that the training program is not feasible.
* Pathological Allen test , In casu no sufficient collateral circulation to the hand, in case of radial artery cannulation.
*MRI will not be part of the studyprotocol in eligible patients with pacemaker/ICD or other contra indications for MRI

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoints:<br /><br>1. Training induced changes in resting cardiac output as determined by cMRI.<br /><br>2. Correlation between training induced changes in resting cardiac output and<br /><br>cardiac output during maximal exercise (LiDCO).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints:<br /><br>Correlation between training induced changes in resting c.q. exercizing<br /><br>cardiac output and changes in the following variables:<br /><br>* Cardiac size at rest (cMRI)<br /><br>* Cardiac output onset and recovery kinetics at submaximal exercise (LiDCO)<br /><br>* Recovery kinetics of muscle tissue oxygenation after submaximal exercise<br /><br>(Near Infrared Spectroscopy)<br /><br>* Quality of life (Minnesota Living With Heart Failure Questionnaire)</p><br>