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Quality of Pediatric Resuscitation in a Multicenter Collaborative

Recruiting
Conditions
Cardiac Arrest
Cardiopulmonary Arrest
Registration Number
NCT02708134
Lead Sponsor
Children's Hospital of Philadelphia
Brief Summary

This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.

The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.

Detailed Description

Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.

Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
5000
Inclusion Criteria
  • Patient received chest compressions for at least 1 minute
  • Patient between gestational age ≥37 weeks and 17 years of age
  • Patient had a quality of CPR measurements device (eg., Zoll Medical chest compression sensor) in place during chest compressions
Exclusion Criteria
  • Patient on extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR10 Years

Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. "Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (47)

Kaiser Permanente

🇺🇸

Los Angeles, California, United States

Cedars-Sinai Medical Center

🇺🇸

Los Angeles, California, United States

Chldren's Hospital of Orange County

🇺🇸

Orange, California, United States

Stanford University

🇺🇸

Palo Alto, California, United States

Rady Children's Hospital

🇺🇸

San Diego, California, United States

Children's Colorado

🇺🇸

Aurora, Colorado, United States

Nemour's Children's Hopistal

🇺🇸

Wilmington, Delaware, United States

All Children's Hospital

🇺🇸

Saint Petersburg, Florida, United States

Children's Healthcare of Atlanta (CHOA)

🇺🇸

Atlanta, Georgia, United States

Comer Children's Hospital

🇺🇸

Chicago, Illinois, United States

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Kaiser Permanente
🇺🇸Los Angeles, California, United States
Gim H Tan
Contact

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