Perioperative characterization of the pulmonary microbiome in cardiovascular risk patients undergoing non-cardiac surgery - a monocentric cohort study.
Recruiting
- Conditions
- Cardiovascular diseases
- Registration Number
- DRKS00027141
- Lead Sponsor
- Charité - Universitätsmedizin Berlin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1) Scheduled elective non-cardiac surgery with intermediate to high risk for cardiac complications
2) General anesthesia with endotracheal intubation
3) Signed informed consent of the participant
Exclusion Criteria
1) Instable cardiac condition (Acute coronary syndrome, Acute heart failure, Tachyarrhythmia or Bradyarrhythmia, symptomatic Aortic stenosis)
2) Emergency surgery
3) Relative contraindication to perform a bronchoalveolar lavage (BAL) (Volume of air exhaled under forced conditions in the first second < 1000 mL, hypercapnia, hypoxemia, hemorrhagic diathesis)
4) Pregnancy
5) Breastfeeding
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentration of bacterial DNA in copies/per mL of bronchoalveolar lavage measured by quantitative polymerase chain reaction after induction of general anesthesia.
- Secondary Outcome Measures
Name Time Method