Comparison of conventional dose with high dose vitamin D in osteoporotic or osteopenic (T Score < -1) women over 50 yrs referring to Shariati Hospital

Not Applicable

• Conditions: Condition 1: osteoprosis. Condition 2: Vitamin D deficiency.; Postmenopausal osteoporosis; Vitamin D deficiency

• Registration Number: IRCT201106126780N1
• Lead Sponsor: Endocrine and Metabolism Research Institute, Tehran Univercsity of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 26

Inclusion Criteria

Inclusion Criteria: Outpatient women over 50 years old who have (T score< -1) in any site on their BMD at Shariati Hospital BMD laboratory.

Exclusion Criteria

Vitamin D supplementation in the last 6 months; Glucocorticoid use in last 3 months; Use of Levothyroxine, anticonvulsant drugs, Lithium, Estrogen, Progesterone, Teriparatide, Cyclosporine; History of : Hyperparathyroidism, Hyperthyroidism, Romatoid Arthritis, Ancylosing Spondylitis, Malignancy, CKD (GFR<30), Premature Ovarian Failure.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum 25(OH) D level. Timepoint: at base, 3rd, 6th and 12th month. Method of measurement: ELISA kits Immunodiagnostic Systems Ltd (IDS), Boldon,UK with 5 nmol/L sensitivity.

Secondary Outcome Measures

Name	Time	Method
Serum Ca. Timepoint: at base, 3rd, 6th and 12th month. Method of measurement: MTB assay, mg/dl.;Serum P. Timepoint: at base, 3rd, 6th and 12th month. Method of measurement: UV assay, mg/dl.;Serum PTH. Timepoint: at base, 3rd, 6th and 12th month. Method of measurement: ELISA kits Immunodiagnostic Systems Ltd (IDS), Boldon,UK , with 0/06 pmol/L sensitivity.;24 Hours Urine for Calcium. Timepoint: at base and 12th month. Method of measurement: MBT assay, mg/dl.