Evaluation of Differential Effects of a Computer-based-cognitive Intervention on Cognition Among Elderly With Mild Cognitive Impairment With and Without White Matter Hyperintensities: A Comparative Study.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Leila DJABELKHIR
- Enrollment
- 51
- Primary Endpoint
- Rey Auditory Verbal Learning test
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.
Detailed Description
White matter hyperintensities (WMH) are increasingly recognized as a factor determining the heterogeneity of Mild Cognitive Impairment (MCI) and have been associated to executive and processing speed impairment. Cognitive interventions in MCI remain quite limited for these MCI with vascular profile and studies often distinguish patients by clinical subtypes rather than brain profile before an intervention. Considering magnetic resonance imaging (MRI) data, this study investigated the effects of a computer-based cognitive stimulation (CCS) program on MCI with WMH compared to MCI without WMH.
Investigators
Leila DJABELKHIR
PhD candidate
Broca Hospital
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of Mild Cognitive Impairment
- •With and without white matter hyperintensities
- •MRI available or accept to perform one
- •No engagement in other cognitive intervention program
Exclusion Criteria
- •Psychiatric and neurological disorders
- •History of alcohol or other substance abuse
- •Sensory and/or motor deficit affecting the use of a tablet
Outcomes
Primary Outcomes
Rey Auditory Verbal Learning test
Time Frame: Baseline assessment, change from Baseline on Rey Auditory Verbal Learning test at 3 months immediately after intervention and at 3 months follow-up
Assessment of verbal learning in episodic memory