A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities

Not Applicable

• Conditions: Mild Cognitive Impairment

• Registration Number: NCT03195816
• Lead Sponsor: Leila DJABELKHIR

Brief Summary

This is a non-pharmacological study evaluating the impact of a computerized cognitive stimulation program on verbal learning and on the progression white matter hyperintensities in elderly with mild cognitive impairment.

Detailed Description

White matter hyperintensities (WMH) can appear in Mild Cognitive Impairment (MCI) and have been associated to executive, attention and processing speed deficits. Some findings indicate that the presence of WMH may contribute to Alzheimer's disease (AD) in addition to ß-amyloid, suggesting a greater vulnerability of MCI. One important challenge is to prevent or slowing down the progression of WMH. Few studies investigated the effects of computerized cognitive interventions in MCI with WMH, which deserve special attention. This study aim to investigate the effects of an intensive computer-based cognitive stimulation (CCS) program on the verbal learning in episodic memory in MCI with WMH and to explore the effects on the progression of WMH at 1-year interval.

Study Timeline

• Status Verified: 2017-06
• Study First Submitted: 2017-06-14
• Study First Submitted QC: 2017-06-20
• Last Update Submitted: 2017-06-20
• Study First Posted: 2017-06-22
• Last Update Posted: 2017-06-22
• Study Start: 2018-01
• Primary Completion: 2018-12
• Study Completion: 2019-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Clinical diagnosis of Mild Cognitive Impairment
• With and without with matter hyperintensities
• MRI data available or accept to perform one
• No engagement in other cognitive intervention program

Exclusion Criteria

• Psychiatric and neurological disorders
• History of alcohol or other substance consumption
• Sensory and or motor deficit that could interfere with the use of computer tool
• Refusal MRI.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change on Rey Auditory Verbal Learning test	Baseline assessment in 3-weeks period before intervention, change from baseline at 6-months immediately after the end intervention, and after 3-months follow-up	Assessment of verbal learning in episodic memory

Secondary Outcome Measures

Name	Time	Method
Change on Fazekas scale	Baseline assessment of WMH severity and evolution at 12 months immediately after intervention	Assessment of white matter hyperintentisites severity on MRI