Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis
Phase 1
- Conditions
- Osteoarthritis of the Knee
- Interventions
- Registration Number
- NCT00833157
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.
The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- Age 50 to 70 years
- Bilateral tibiofemoral osteoarthritis of the knee on x-ray
- American College of Rheumatology (ACR) clinical classification criteria
Exclusion Criteria
- Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases
- Excess alcohol use (> 21 alcoholic drinks per week)
- Severe overweight (BMI > 35)
- History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Glucosamine glucosamine sulphate - Placebo placebo - Ibuprofen ibuprofen -
- Primary Outcome Measures
Name Time Method muscle strength and hypertrophy We measure before and after 12-weeks strength training. cartilage biomarkers We measure before and after 12 weeks strength training
- Secondary Outcome Measures
Name Time Method muscle regeneration and function We measure before and after 12-weeks strength training.