Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

Phase 1

• Conditions: Osteoarthritis of the Knee
• Interventions: Drug: glucosamine sulphate; Drug: placebo; Drug: ibuprofen

• Registration Number: NCT00833157
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.

The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-02
• Primary Completion: 2007-07
• Status Verified: 2009-01
• Study First Submitted: 2009-01-29
• Study First Submitted QC: 2009-01-29
• Last Update Submitted: 2009-01-29
• Study First Posted: 2009-01-30
• Last Update Posted: 2009-01-30
• Study Completion: 2009-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Age 50 to 70 years
• Bilateral tibiofemoral osteoarthritis of the knee on x-ray
• American College of Rheumatology (ACR) clinical classification criteria

Exclusion Criteria

• Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases
• Excess alcohol use (> 21 alcoholic drinks per week)
• Severe overweight (BMI > 35)
• History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Glucosamine	glucosamine sulphate	-
Placebo	placebo	-
Ibuprofen	ibuprofen	-

Primary Outcome Measures

Name	Time	Method
muscle strength and hypertrophy	We measure before and after 12-weeks strength training.
cartilage biomarkers	We measure before and after 12 weeks strength training

Secondary Outcome Measures

Name	Time	Method
muscle regeneration and function	We measure before and after 12-weeks strength training.