Postoperative bowel dysfunction: effect of less opioid anesthesia and enhanced recovery after complex spine surgery: prospective randomized controlled trial

Phase 4

• Conditions: elective complex spine surgery

• Registration Number: TCTR20201229001
• Lead Sponsor: faculty of medicine siriaj hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-29
• Study Completion: 2022-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

ASA class 1-3
Elective surgery
thoracic or lumbar complex spine surgery (spinal instrument or more than 3 level )

Exclusion Criteria

patient refusal
Cr > 2 mg/dL , eGFR < 50ml/min
patient with caronary artery disease, congestive heart failure
pateint with cerebrovascular disease, seizure
BMI > 30 kg/m2. or body weight < 50 kg
patient with spinal cord injury (complete cord lesion)
patient with spinal tumor
intraoperative neuromonitorings
uncontrolled hypertension (BP > 180/110)
constipation (defecation 2days/time) or use of laxatives
patient with irritable bowel syndrome
previous abdominal surgery
patient recieved calcium channel blocker
allergy to gabapentin, ketamine, magnesium, dexamethasone, lidocaine, dexamathesone, parecoxib, morphine,fentanyl
disable to use intravenous patient controlled analgesia
communication problem
preoperative unstable hemodynamics

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence of postopeartive bowel dysfunction 12 months first postoperative defecation before 48 hours

Secondary Outcome Measures

Name	Time	Method
incidences of nausea vomiting, 12 months incidence,incidences of abdominal distention 12 months incidence,incidences of fart before 48 hours 12 months incidence,dietary habit 12 months subjective measurement