The Role of the Endocannabinoid System in Sweet Taste Intensity and Liking
Completed
- Conditions
- ObesitasObesityoverweight10003018
- Registration Number
- NL-OMON40528
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
Male
Healthy
Incidental user of Cannabis
Exclusion Criteria
Previously experienced an adverse reaction to cannabinoids (e.g. anxiety, paranoia, naussea, vomiting)
Having a family history of schizophrenia or other psychotic ilness
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the sucrose intensity scaling (psychophysics) and<br /><br>liking (psychohedonics) of the milkshakes with the different sucrose<br /><br>concentrations.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The first secondary objective it to assess if cannabinoids influence the<br /><br>preferred sucrose concentration and the total amount of milkshake consumed in<br /><br>the preference task.<br /><br>The second secondary objective is to see if the blood levels of<br /><br>endocannabinoids, leptin, ghrelin and insulin change during the course of the<br /><br>session and if there are differences between sessions.<br /><br>The third secondary objective is to follow plasma levels of THC or CBD and<br /><br>their active metabolites.<br /><br>The fourth secondary study objective is changes in liking of food products and<br /><br>in food choice in the food preference task. This also includes reaction time<br /><br>for the food choice questions.<br /><br>The fifth and final secondary study objective is the genetic determination of<br /><br>the enzymes responsible for the metabolism of THC and CBD.</p><br>