The role of nutritional interventions in the fight against antimicrobial resistance

Not Applicable

• Conditions: Antimicrobial Resistance; Acute infection treated with antibiotics; Inflammatory and Immune System - Other inflammatory or immune system disorders; Infection - Other infectious diseases

• Registration Number: ACTRN12622000484741
• Lead Sponsor: CSIRO

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-28
• Last Update Posted: 19 April 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1.Willing to provide written Informed Consent
2.Able to access own email inbox
3.Be able to attend the CSIRO nutrition clinic for around 2.5 hours on two occasions across an eight-week period.
4.Willing to consume their regular habitual diet throughout the study period
5.Adults (males and females)
6. =18-<66 years of age at clinic screen
7.BMI of =18.5 - =35 kg/m2
8.An episode of acute infection (any type) requiring at least one course of antibiotics in the past 3 months*
*Self-reported, no clinical testing will be performed

Exclusion Criteria

1.Health conditions* that could affect gut and immune health such as gastrointestinal diseases [including, but not limited to diverticulitis, ulcerative colitis, Crohn’s disease, or coeliac disease, colostomy], type 1 or type 2 diabetes, cancer, renal or liver diseases in the last 12 months.
2.Immunocompromised (diagnosed with HIV, AIDS) or having an organ or bone marrow transplant in the last 12 months.
3.Gastrointestinal symptoms* (i.e. pain, reflux, diarrhea, or constipation), surgeries* (i.e. bariatric surgery such as gastric banding) or use of medications* (i.e. appetite suppressants (orlistat, phentermine and liraglutide), steroids (corticosteroids, progestogen, androgens and estrogens) known to potentially affect energy intake, appetite, or gastrointestinal motor function
4.Have a biliary disorder
5.Currently taking medication for hypertension and or high cholesterol
6.Currently taking supplements (probiotics, prebiotics, fibre, micronutrients, multivitamins, essential oils) or functional foods (fermented food, polyphenols) in the previous 4 weeks of Visit 1.
7.Known food allergies or intolerances to the study intervention products
8.Pregnant and/or lactating women
9.Current smoker (or history of smoking within the last six months)
10.History of or known presence of alcohol abuse or illicit drug use*
11.Received an investigational drug within 28 days prior to Visit 1 that in the opinion of the investigator may affect the applicant’s ability to participate in the study or the study results
*Self-reported, no clinical testing will be performed

Study & Design

• Study Type: Interventional
• Study Design: Not specified