Concurrent versus sequential neoadjuvant chemo-radiotherapy followed by surgery in operable carcinoma gallbladder patients: A pilot study

All India Institute of Medical Sciences0 个研究点目标入组 16 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•a) Subjects with FNAC-proven Gall bladder adenocarcinoma (up to operable stage IVA) which is potentially resectable by preoperative imaging
•b) Performance status ECOG-1&2
•c) Normal renal, hepatic, and hematologic function at the time of enrolment
•d) Age 18-65 years

•a) Patient refusal
•b) Poor performance status (ECOG â?? 3&4)
•c) Major co-morbid conditions like cirrhosis, renal failure, uncontrolled hypertension or cardiac failure -
•d) Subjects who have received chemotherapy within 12 months prior to study entry.
•e) Prior use of radiotherapy.
•f) Subjects who have undergone previous surgery on gall bladder/biliary tree.
•g) Any evidence of metastasis to distant organs (liver, lung, peritoneum).
•h) Non-contiguous liver metastasis (M1 disease).
•i) Major vascular involvement such as proper hepatic artery involvement and main portal vein involvement (T4 â?? inoperable disease).
•j) Periaortic, Pericaval, Superior mesenteric artery and/or Celiac artery lymph node involvement (N2 disease) â?? confirmed by FNAC.

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